Drug addiction and its effect on the behavior and development of children has become a serious problem in our society. Methamphetamine (MA) is one of the most abused psychostimulants in the Czech Republic, and its abuse is rising worldwide. Previous studies have demonstrated the adverse long-term effects of maternal drug abuse on rat offspring. However, the father's contribution as a parent and donor of half of the genetic information is unclear. Previous studies of other psychostimulant drugs indicate that long-term application of MA to adult male rats may induce changes in their reproductive system and lead to changes in rat pup functional and behavioral development. Therefore, the present review aimed to investigate the effect of MA administration on reproductive toxicity and sexual behavior of adult male rats, as well as the impact of paternal MA exposure on behavioral development and locomotor activity in rat offspring.

• MeSH
• Behavior, Animal MeSH
• Child MeSH
• Adult MeSH
• Rats MeSH
• Humans MeSH
• Methamphetamine * adverse effects   MeSH
• Genitalia MeSH
• Rats, Wistar MeSH
• Sexual Behavior MeSH
• Central Nervous System Stimulants * pharmacology   MeSH
• Prenatal Exposure Delayed Effects * chemically induced   MeSH
• Animals MeSH
• Check Tag
• Child MeSH
• Adult MeSH
• Rats MeSH
• Humans MeSH
• Male MeSH
• Female MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Review MeSH
• Names of Substances
• Methamphetamine * MeSH
• Central Nervous System Stimulants * MeSH

Methamphetamine (MA) is one of the most abused psychostimulants in the Czech Republic and worldwide. Previous studies have demonstrated the adverse effects of maternal drug abuse. However, the father's contribution as a parent and donor of the half genetic information is unclear. The present study aimed to examine the effect of paternal MA exposure on behavioral development and locomotor activity in rat offspring. MA was administrated subcutaneously for 30 days at a dose of 5 mg/kg to adult male rats. The impact of paternal MA exposure on rat pups was investigated using behavioral tests during development and locomotor activity tests in adulthood. Prior to testing, adult offspring were exposed to an acute challenge dose of MA (1 mg/kg) to examine the possible sensitizing effect of the paternal treatment. Our results found no significant differences in behavioral development or locomotor activity in adulthood of offspring linked to paternal MA application. These results differ from the effects induced by maternal MA application. Further, our results demonstrated a significant increase in locomotor activity on the Laboras test after acute MA application. When comparing sex differences, females showed more activity than males in adulthood, whereas males were more active during development.

• MeSH
• Behavior, Animal drug effects   MeSH
• Rats MeSH
• Locomotion drug effects   MeSH
• Methamphetamine toxicity   MeSH
• Rotarod Performance Test MeSH
• Paternal Exposure * MeSH
• Sex Characteristics MeSH
• Reflex, Righting drug effects   MeSH
• Rats, Wistar MeSH
• Sensorimotor Cortex drug effects   growth & development   MeSH
• Sex Factors MeSH
• Central Nervous System Stimulants toxicity   MeSH
• Age Factors MeSH
• Animals MeSH
• Check Tag
• Rats MeSH
• Male MeSH
• Female MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Comparative Study MeSH
• Names of Substances
• Methamphetamine MeSH
• Central Nervous System Stimulants MeSH