BACKGROUND: Intra-articular hyaluronic acid (IAHA) products are often used in the treatment of adults with mild-to-moderate knee osteoarthritis (KOA). The International Symposium on Intra-Articular Treatment (ISIAT) convened a multidisciplinary technical expert panel to define characteristics for an innovative IAHA product that should answer unmet needs in the clinical management of adults with mild-to-moderate KOA. METHODS: An initial set of evidence-based statements was developed based on data extracted from articles identified through a comprehensive literature search. A Delphi panel comprising 19 experts in KOA voted in 3 rounds to rate their degree of agreement with accepted statements. RESULTS: The final set of 13 accepted statements focus on the effect of an innovative IAHA across 5 key domains of nociceptive pain, joint function, quality of life, joint structure and integrity, and adverse effects. The statements set thresholds for clinically meaningful improvements that exceed those generally achievable by currently available IAHA products. CONCLUSION: The characteristics described by these statements from the ISIAT set new standards for what should be expected from an innovative IAHA. These statements should serve as a framework for driving the development of innovative IAHA products that will surpass the actual outcomes achieved by current viscosupplements in patients with mild-to-moderate KOA.

• Klíčová slova
• consensus, innovative, intra-articular hyaluronic acid, knee osteoarthritis,
• Publikační typ
• časopisecké články MeSH

• MeSH
• artróza kolenních kloubů diagnóza   farmakoterapie   patofyziologie   MeSH
• biomechanika MeSH
• injekce intraartikulární MeSH
• kolenní kloub účinky léků   patofyziologie   MeSH
• kyselina hyaluronová aplikace a dávkování   škodlivé účinky   MeSH
• lidé MeSH
• obnova funkce MeSH
• rozsah kloubních pohybů MeSH
• směrnice pro lékařskou praxi jako téma MeSH
• viskoelastické doplňky kloubní tekutiny aplikace a dávkování   škodlivé účinky   MeSH
• viskosuplementace škodlivé účinky   metody   normy   MeSH
• výsledek terapie MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH
• Názvy látek
• kyselina hyaluronová MeSH
• viskoelastické doplňky kloubní tekutiny MeSH