The effect of recombinant divercin RV41 (DvnRV41) and its structural variants on the K-channel formation was determined. The growth of Listeria monocytogenes EGDe (sensitive phenotype) and its isogenic strain (resistant phenotype) was assessed in the presence of DvnRV41 combined or not with pinacidil, NS1619, cromakalim (as K-channel activators), iberiotoxin and glipizide (as K-channel blockers). The combined action of DvnRV41 and K activators permitted formation of ATP-dependent pores. The combination of DvnRV41 and ATP-dependent pore activator cromakalim inhibited the growth of sensitive strain. The antilisterial activity of structural variants was less important than that of DvnRV41 but their mode of action remained overall similar.

• MeSH
• Adenosine Triphosphate metabolism   MeSH
• Anti-Bacterial Agents metabolism   MeSH
• Bacteriocins genetics   metabolism   MeSH
• Potassium Channel Blockers metabolism   MeSH
• Potassium Channels agonists   metabolism   MeSH
• Listeria monocytogenes drug effects   genetics   growth & development   metabolism   MeSH
• Microbial Sensitivity Tests MeSH
• Recombinant Proteins genetics   metabolism   MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Names of Substances
• Adenosine Triphosphate MeSH
• Anti-Bacterial Agents MeSH
• Bacteriocins MeSH
• Potassium Channel Blockers MeSH
• divercin V41 MeSH Browser
• Potassium Channels MeSH
• Recombinant Proteins MeSH