The SorC family is a large group of bacterial transcription regulators involved in controlling carbohydrate catabolism and quorum sensing. SorC proteins consist of a conserved C-terminal effector-binding domain and an N-terminal DNA-binding domain, whose type divides the family into two subfamilies: SorC/DeoR and SorC/CggR. Proteins of the SorC/CggR subfamily are known to regulate the key node of glycolysis-triose phosphate interconversion. On the other hand, SorC/DeoR proteins are involved in a variety of peripheral carbohydrate catabolic pathways and quorum sensing functions, including virulence. Despite the abundance and importance of this family, SorC proteins seem to be on the periphery of scientific interest, which might be caused by the fragmentary information about its representatives. This review aims to compile the existing knowledge and provide material to inspire future questions about the SorC protein family.

• Klíčová slova
• SorC family, bacterial transcription regulation, carbohydrate metabolism, quorum sensing,
• MeSH
• Bacteria * metabolismus   genetika   MeSH
• bakteriální proteiny * metabolismus   chemie   genetika   MeSH
• quorum sensing MeSH
• regulace genové exprese u bakterií MeSH
• transkripční faktory * metabolismus   chemie   genetika   MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• bakteriální proteiny * MeSH
• transkripční faktory * MeSH

The effect of recombinant divercin RV41 (DvnRV41) and its structural variants on the K-channel formation was determined. The growth of Listeria monocytogenes EGDe (sensitive phenotype) and its isogenic strain (resistant phenotype) was assessed in the presence of DvnRV41 combined or not with pinacidil, NS1619, cromakalim (as K-channel activators), iberiotoxin and glipizide (as K-channel blockers). The combined action of DvnRV41 and K activators permitted formation of ATP-dependent pores. The combination of DvnRV41 and ATP-dependent pore activator cromakalim inhibited the growth of sensitive strain. The antilisterial activity of structural variants was less important than that of DvnRV41 but their mode of action remained overall similar.

• MeSH
• adenosintrifosfát metabolismus   MeSH
• antibakteriální látky metabolismus   MeSH
• bakteriociny genetika   metabolismus   MeSH
• blokátory draslíkových kanálů metabolismus   MeSH
• draslíkové kanály agonisté   metabolismus   MeSH
• Listeria monocytogenes účinky léků   genetika   růst a vývoj   metabolismus   MeSH
• mikrobiální testy citlivosti MeSH
• rekombinantní proteiny genetika   metabolismus   MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• adenosintrifosfát MeSH
• antibakteriální látky MeSH
• bakteriociny MeSH
• blokátory draslíkových kanálů MeSH
• divercin V41 MeSH Prohlížeč
• draslíkové kanály MeSH
• rekombinantní proteiny MeSH