Comparative analysis of ospC genes from 127 Borrelia burgdorferi sensu stricto strains collected in European and North American regions where Lyme disease is endemic and where it is not endemic revealed a close relatedness of geographically distinct populations. ospC alleles A, B, and L were detected on both continents in vectors and hosts, including humans. Six ospC alleles, A, B, L, Q, R, and V, were prevalent in Europe; 4 of them were detected in samples of human origin. Ten ospC alleles, A, B, D, E3, F, G, H, H3, I3, and M, were identified in the far-western United States. Four ospC alleles, B, G, H, and L, were abundant in the southeastern United States. Here we present the first expanded analysis of ospC alleles of B. burgdorferi strains from the southeastern United States with respect to their relatedness to strains from other North American and European localities. We demonstrate that ospC genotypes commonly associated with human Lyme disease in European and North American regions where the disease is endemic were detected in B. burgdorferi strains isolated from the non-human-biting tick Ixodes affinis and rodent hosts in the southeastern United States. We discovered that some ospC alleles previously known only from Europe are widely distributed in the southeastern United States, a finding that confirms the hypothesis of transoceanic migration of Borrelia species.

• MeSH
• alely * MeSH
• antigeny bakteriální genetika   MeSH
• Borrelia burgdorferi genetika   izolace a purifikace   MeSH
• DNA bakterií chemie   genetika   MeSH
• genetická variace MeSH
• genotyp MeSH
• hlodavci mikrobiologie   MeSH
• klíště mikrobiologie   MeSH
• lidé MeSH
• molekulární sekvence - údaje MeSH
• proteiny vnější bakteriální membrány genetika   MeSH
• sekvenční analýza DNA MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Research Support, N.I.H., Extramural MeSH
• Research Support, U.S. Gov't, P.H.S. MeSH
• Geografické názvy
• Evropa MeSH
• Severní Amerika MeSH
• Názvy látek
• antigeny bakteriální MeSH
• DNA bakterií MeSH
• OspC protein MeSH Prohlížeč
• proteiny vnější bakteriální membrány MeSH