The aim of our study was to analyse inherited thrombotic disorders that influence the long-term outcome of PTA. Methods. Diabetic patients with peripheral arterial disease (PAD) treated by PTA in our centre between 2008 and 2011 were included in the study. Patients were divided into unsuccessful PTA group (75 patients), successful PTA group (58 patients), and control group (65 patients, with diabetes but no PAD). Diagnosis of inherited thrombotic disorders included mutation in factor V (Leiden), factor II (prothrombin), and mutation in genes for methylenetetrahydrofolate reductase-MTHFR (C677T and A1298C). Results. The genotypic frequency of Leiden allele G1691A was significantly associated with a risk of unsuccessful PTA in comparison with successful PTA group and control group (OR 8.8 (1.1-70.6), p = 0.041, and OR 9.8 (1.2-79.2), p = 0.032, resp.). However, we only observed a trend for the association of the prothrombin allele G20210A and risk of PTA failure. The frequencies of alleles of MTHFR 677 or 1298 did not differ significantly among the groups. Conclusion. Our study showed higher frequency of heterozygous form of Leiden mutation in diabetic patients with unsuccessful outcome of PTA in comparison with patients with successful PTA and diabetic patients without PAD.

• MeSH
• angioplastika škodlivé účinky   MeSH
• bérec krevní zásobení   MeSH
• bodová mutace * MeSH
• diabetické angiopatie etiologie   patofyziologie   terapie   MeSH
• faktor V analýza   genetika   MeSH
• genetické asociační studie MeSH
• ischemie epidemiologie   etiologie   prevence a kontrola   MeSH
• lidé středního věku MeSH
• lidé MeSH
• methylentetrahydrofolátreduktasa (NADPH2) krev   genetika   MeSH
• paže krevní zásobení   MeSH
• prevalence MeSH
• protrombin analýza   genetika   MeSH
• průřezové studie MeSH
• recidiva MeSH
• senioři MeSH
• substituce aminokyselin MeSH
• trombofilie krev   komplikace   genetika   patofyziologie   MeSH
• trombóza komplikace   etiologie   patofyziologie   terapie   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• klinické zkoušky kontrolované MeSH
• práce podpořená grantem MeSH
• Geografické názvy
• Česká republika epidemiologie   MeSH
• Názvy látek
• factor V Leiden MeSH Prohlížeč
• faktor V MeSH
• methylentetrahydrofolátreduktasa (NADPH2) MeSH
• MTHFR protein, human MeSH Prohlížeč
• protrombin MeSH