One approach for the enhancement of oral drug bioavailability is the technique of nanoparticle preparation. Risedronate sodium (Biopharmaceutical Classification System Class III) was chosen as a model compound with high water solubility and low intestinal permeability. Eighteen samples of risedronate sodium were prepared by the solvent evaporation technique with sodium dodecyl sulfate, polysorbate, macrogol, sodium carboxymethyl cellulose and sodium carboxymethyl dextran as nanoparticle stabilizers applied in three concentrations. The prepared samples were characterized by dynamic light scattering and scanning electron microscopy. Fourier transform mid-infrared spectroscopy was used for verification of the composition of the samples. The particle size of sixteen samples was less than 200 nm. Polysorbate, sodium carboxymethyl dextran and macrogol were determined as the most favourable excipients; the particle size of the samples of risedronate with these excipients ranged from 2.8 to 10.5 nm.

• MeSH
• Biological Availability MeSH
• Dextrans chemistry   MeSH
• Calorimetry, Differential Scanning methods   MeSH
• Sodium Dodecyl Sulfate chemistry   MeSH
• Technology, Pharmaceutical methods   MeSH
• Etidronic Acid analogs & derivatives   chemistry   MeSH
• Risedronic Acid MeSH
• Microscopy, Electron, Scanning methods   MeSH
• Nanoparticles chemistry   MeSH
• Drug Carriers chemistry   MeSH
• Permeability MeSH
• Polyethylene Glycols chemistry   MeSH
• Polysorbates chemistry   MeSH
• Excipients chemistry   MeSH
• Solvents chemistry   MeSH
• Solubility MeSH
• Carboxymethylcellulose Sodium chemistry   MeSH
• Particle Size MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Names of Substances
• carboxymethyl dextran MeSH Browser
• Dextrans MeSH
• Sodium Dodecyl Sulfate MeSH
• Etidronic Acid MeSH
• Risedronic Acid MeSH
• Drug Carriers MeSH
• Polyethylene Glycols MeSH
• Polysorbates MeSH
• Excipients MeSH
• Solvents MeSH
• Carboxymethylcellulose Sodium MeSH