Liquid chromatography (LC) coupled with mass spectrometry (MS) is widely used for the determination of mycotoxins in cereals and cereal-based products. In addition to the regulated mycotoxins, for which official control is required, LC-MS is often used for the screening of a large range of mycotoxins and/or for the identification and characterization of novel metabolites. This review provides insight into the LC-MS methods used for the determination of co-occurring mycotoxins with special emphasis on multiple-analyte applications. The first part of the review is focused on targeted LC-MS approaches using cleanup methods such as solid-phase extraction and immunoaffinity chromatography, as well as on methods based on minimum cleanup (quick, easy, cheap, effective, rugged, and safe; QuEChERS) and dilute and shoot. The second part of the review deals with the untargeted determination of mycotoxins by LC coupled with high-resolution MS, which includes also metabolomics techniques to study the fate of mycotoxins in plants.

• Klíčová slova
• Fungal secondary metabolites, Liquid chromatography–high-resolution mass spectrometry, Liquid chromatography–tandem mass spectrometry, Metabolomics, Validation,
• MeSH
• analýza potravin metody   MeSH
• chromatografie afinitní metody   MeSH
• extrakce na pevné fázi metody   MeSH
• houby izolace a purifikace   metabolismus   MeSH
• jedlá semena chemie   metabolismus   mikrobiologie   MeSH
• metabolomika metody   MeSH
• mykotoxiny analýza   metabolismus   MeSH
• tandemová hmotnostní spektrometrie metody   MeSH
• vysokoúčinná kapalinová chromatografie metody   MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• mykotoxiny MeSH