B-cell activating factor (BAFF) is a cytokine and adipokine of the TNF ligand superfamily. The main biological function of BAFF in maintaining the maturation of B-cells to plasma cells has recently made it a target of the first FDA-approved selective BAFF antibody, belimumab, for the therapy of systemic lupus erythematosus. Concomitantly, the role of BAFF in cancer has been a subject of research since its discovery. Here we review BAFF as a biomarker of malignant disease activity and prognostic factor in B-cell derived malignancies such as multiple myeloma. Moreover, anti-BAFF therapy seems to be a promising approach in treatment of B-cell derived leukemias/lymphomas. In nonhematologic solid tumors, BAFF may contribute to cancer progression by mechanisms both dependent on and independent of BAFF's proinflammatory role. We also describe ongoing research into the pathophysiological link between BAFF and cancer-related cachexia. BAFF has been shown to contribute to inflammation and insulin resistance which are known to worsen cancer cachexia syndrome. Taking all the above together, BAFF is emerging as a biomarker of several malignancies and a possible hallmark of cancer cachexia.

• MeSH
• B-lymfocyty metabolismus   patologie   MeSH
• faktor aktivující B-buňky genetika   MeSH
• humanizované monoklonální protilátky terapeutické užití   MeSH
• kachexie genetika   patologie   MeSH
• lidé MeSH
• mnohočetný myelom genetika   patologie   MeSH
• monoklonální protilátky terapeutické užití   MeSH
• nádorové biomarkery genetika   MeSH
• systémový lupus erythematodes farmakoterapie   genetika   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH
• Názvy látek
• belimumab MeSH Prohlížeč
• faktor aktivující B-buňky MeSH
• humanizované monoklonální protilátky MeSH
• monoklonální protilátky MeSH
• nádorové biomarkery MeSH
• TNFSF13B protein, human MeSH Prohlížeč