BACKGROUND: Cognitive rehabilitation is a highly individualised, non-pharmacological intervention for people with mild cognitive impairment (MCI) and dementia, which in recent years has also been developed for various IT platforms. METHODS: In this study, we aim to evaluate the effectiveness of the cognitive rehabilitation software GRADIOR in a multi-centre, single-blinded randomised controlled trial with people with MCI and mild dementia. A total of 400 people with MCI and mild dementia will be randomly allocated to one of four groups. This trial will compare the cognitive rehabilitation treatment using the GRADIOR programme with a psychosocial stimulation intervention (PSS) using the ehcoBUTLER platform, with a combined treatment consisting of GRADIOR and ehcoBUTLER, and with a group receiving treatment as usual during a period of 1 year. DISCUSSION: The outcomes of this clinical trial will be to determine any relevant changes in cognition, mood, quality of life, activities of daily living and quality of patient-carer relationship after 4 months and 1 year of intervention in a cross-sectional group comparison. Participants will be followed-up for 1 year to investigate potential long-term effects of the conducted treatments. TRIAL REGISTRATION: Current Controlled Trials ISRCTN, ID: 15742788 . Registered on 12 June 2017.

• Klíčová slova
• Alzheimer’s disease, Cognition, Cognitive intervention, Cognitive rehabilitation, Computer-based intervention, Dementia, MCI, Psychosocial intervention,
• MeSH
• afekt MeSH
• časové faktory MeSH
• činnosti denního života MeSH
• demence diagnóza   psychologie   rehabilitace   MeSH
• jednoduchá slepá metoda MeSH
• kognice * MeSH
• kognitivní dysfunkce diagnóza   psychologie   rehabilitace   MeSH
• kvalita života MeSH
• lidé středního věku MeSH
• lidé MeSH
• multicentrické studie jako téma MeSH
• počítačem asistovaná terapie metody   MeSH
• psychoterapie metody   MeSH
• randomizované kontrolované studie jako téma MeSH
• senioři MeSH
• software * MeSH
• stupeň závažnosti nemoci MeSH
• výsledek terapie MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• protokol klinické studie MeSH
• Geografické názvy
• Španělsko MeSH