BACKGROUND: Cognitive rehabilitation is a highly individualised, non-pharmacological intervention for people with mild cognitive impairment (MCI) and dementia, which in recent years has also been developed for various IT platforms. METHODS: In this study, we aim to evaluate the effectiveness of the cognitive rehabilitation software GRADIOR in a multi-centre, single-blinded randomised controlled trial with people with MCI and mild dementia. A total of 400 people with MCI and mild dementia will be randomly allocated to one of four groups. This trial will compare the cognitive rehabilitation treatment using the GRADIOR programme with a psychosocial stimulation intervention (PSS) using the ehcoBUTLER platform, with a combined treatment consisting of GRADIOR and ehcoBUTLER, and with a group receiving treatment as usual during a period of 1 year. DISCUSSION: The outcomes of this clinical trial will be to determine any relevant changes in cognition, mood, quality of life, activities of daily living and quality of patient-carer relationship after 4 months and 1 year of intervention in a cross-sectional group comparison. Participants will be followed-up for 1 year to investigate potential long-term effects of the conducted treatments. TRIAL REGISTRATION: Current Controlled Trials ISRCTN, ID: 15742788 . Registered on 12 June 2017.

Centre of Gerontology Faculty of Humanities Charles University Prague Czech Republic

Ciber Fisiopatología Obesidad y Nutrición CB06 03 Instituto Salud Carlos 3 Madrid Spain

Department of Basic and Clinical Psychology and Psychobiology Universitat Jaume 1 Castellón Spain

Faculty of Education University of Salamanca Salamanca Spain

Faculty of Psychology University of Salamanca Salamanca Spain

Institute of Biomedical Research University of Salamanca Salamanca Spain

INTRAS Foundation Ctra de la Hiniesta 137 49024 Zamora Spain

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