Status epilepticus (SE) is the most common neurologic emergency in children. Both clinical and laboratory studies have demonstrated that SE in early life can cause brain damage and permanent behavioral abnormalities, trigger epileptogenesis, and interfere with normal brain development. In experimental rodent models, the consequences of seizures are dependent upon age, the model used, and seizure duration. In studies involving neonatal and infantile animals, the model used, experimental design, conditions during the experiment, and manipulation of animals can significantly affect the course of the experiments as well as the results obtained. Standardization of laboratory approaches, harmonization of scientific methodology, and improvement in data collection can improve the comparability of data among laboratories.

• Klíčová slova
• animal models, comorbidites, immature rodent, status epilepticus,
• MeSH
• laboratorní zvířata MeSH
• modely nemocí na zvířatech MeSH
• mozek MeSH
• status epilepticus * MeSH
• záchvaty MeSH
• zvířata MeSH
• Check Tag
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

Endo- as well as exogenous adenosine exhibits anticonvulsant action. Participation of individual types of adenosine receptors was studied in present experiments in immature rats. Cortical epileptic afterdischarges were used as a model in rat pups 12, 18 and 25 days old. CCPA, an agonist of A1 adenosine receptors, decreased markedly duration of afterdischarges whereas DPCPX, an antagonist of A1 receptors, exhibited strong proconvulsant action. Action of either drug was best expressed in 12-day-old rats and it decreased with age. Drugs influencing A2A adenosine receptors (agonist CGS21680 and antagonist ZM241385) did not exhibit systematic effects in our model. Motor phenomena accompanying cortical stimulation or epileptic afterdischarge were never influenced by any of the four drugs studied. A1 adenosine receptors are important in the model of cortical seizures, especially in the youngest group studied.

• MeSH
• akční potenciály účinky léků   fyziologie   MeSH
• analýza rozptylu MeSH
• biofyzika MeSH
• elektrická stimulace MeSH
• krysa rodu Rattus MeSH
• mozková kůra cytologie   růst a vývoj   MeSH
• novorozená zvířata MeSH
• potkani Wistar MeSH
• purinergní látky farmakologie   MeSH
• receptor adenosinový A1 metabolismus   MeSH
• receptory adenosinové A2 metabolismus   MeSH
• věkové faktory MeSH
• vztah mezi dávkou a účinkem léčiva MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• purinergní látky MeSH
• receptor adenosinový A1 MeSH
• receptory adenosinové A2 MeSH