The degradation of maternally provided molecules is a very important process during early embryogenesis. However, the vast majority of studies deals with mRNA degradation and protein degradation is only a very little explored process yet. The aim of this article was to summarize current knowledge about the protein degradation during embryogenesis of mammals. In addition to resuming of known data concerning mammalian embryogenesis, we tried to fill the gaps in knowledge by comparison with facts known about protein degradation in early embryos of non-mammalian species. Maternal protein degradation seems to be driven by very strict rules in terms of specificity and timing. The degradation of some maternal proteins is certainly necessary for the normal course of embryonic genome activation (EGA) and several concrete proteins that need to be degraded before major EGA have been already found. Nevertheless, the most important period seems to take place even before preimplantation development-during oocyte maturation. The defects arisen during this period seems to be later irreparable.

• Klíčová slova
• Autophagy, Embryonic genome activation, Maternal to zygotic transition, Proteasome system, Ubiquitin, Ubiquitin ligase,
• MeSH
• embryo nesavčí metabolismus   fyziologie   MeSH
• embryo savčí metabolismus   fyziologie   MeSH
• embryonální vývoj fyziologie   MeSH
• genom fyziologie   MeSH
• lidé MeSH
• oocyty metabolismus   fyziologie   MeSH
• proteiny metabolismus   MeSH
• vývojová regulace genové exprese fyziologie   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• proteiny MeSH

The period for which oocyte-derived factors are engaged in the control of human embryonic development involves at least the first four cell cycles after fertilization. The maternal-embryonic transition in humans 8- to 16-cell embryos is a relatively vulnerable process, the failure of which entails developmental arrest of the given blastomere. The very early cellular differentiative events in human embryos, including blastomere surface polarization and segregation of the inner cell mass and trophectoderm cell lineages, appear to be dependent largely on the maternal genetic program. However, the embryonic genome is required for the formation of the blastocyst cavity, which is necessary to allow further differentiation of the first two embryonic tissues. Blastomeres with major developmental defects are removed by fragmentation and their loss is compensated by proliferation of remaining normal blastomeres. This mechanism is also mainly responsible for the regulation of ploidy through elimination of aneuploid blastomeres. The data presented suggest that embryos of individual mammalian species may differ in the timing of relevant developmental changes at the cellular and molecular levels. This should be taken into account when findings obtained on embryos of one species are used to anticipate the behavior of embryos of another species under identical conditions.

• MeSH
• blastocysta fyziologie   MeSH
• blastomery fyziologie   MeSH
• druhová specificita MeSH
• embryo savčí fyziologie   MeSH
• lidé MeSH
• ploidie MeSH
• těhotenství MeSH
• Check Tag
• lidé MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• srovnávací studie MeSH