The neglected part of early embryonic development: maternal protein degradation
Jazyk angličtina Země Švýcarsko Médium print-electronic
Typ dokumentu časopisecké články, přehledy
Grantová podpora
CIGA 20172013
Internal Grant Agency of the Czech University of Life Sciences
GACR 13-24730P
Grantová Agentura České Republiky
FNU 8021-00048B
Danish Council for Independent Research/Natural Sciences
PubMed
32095869
PubMed Central
PMC11104927
DOI
10.1007/s00018-020-03482-2
PII: 10.1007/s00018-020-03482-2
Knihovny.cz E-zdroje
- Klíčová slova
- Autophagy, Embryonic genome activation, Maternal to zygotic transition, Proteasome system, Ubiquitin, Ubiquitin ligase,
- MeSH
- embryo nesavčí metabolismus fyziologie MeSH
- embryo savčí metabolismus fyziologie MeSH
- embryonální vývoj fyziologie MeSH
- genom fyziologie MeSH
- lidé MeSH
- oocyty metabolismus fyziologie MeSH
- proteiny metabolismus MeSH
- vývojová regulace genové exprese fyziologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- proteiny MeSH
The degradation of maternally provided molecules is a very important process during early embryogenesis. However, the vast majority of studies deals with mRNA degradation and protein degradation is only a very little explored process yet. The aim of this article was to summarize current knowledge about the protein degradation during embryogenesis of mammals. In addition to resuming of known data concerning mammalian embryogenesis, we tried to fill the gaps in knowledge by comparison with facts known about protein degradation in early embryos of non-mammalian species. Maternal protein degradation seems to be driven by very strict rules in terms of specificity and timing. The degradation of some maternal proteins is certainly necessary for the normal course of embryonic genome activation (EGA) and several concrete proteins that need to be degraded before major EGA have been already found. Nevertheless, the most important period seems to take place even before preimplantation development-during oocyte maturation. The defects arisen during this period seems to be later irreparable.
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