Gene expression and chromatin structure in the pre-implantation embryo
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
12499014
DOI
10.1016/s0093-691x(02)01267-0
PII: S0093691X02012670
Knihovny.cz E-zdroje
- MeSH
- chromatin ultrastruktura MeSH
- embryonální vývoj * MeSH
- histony genetika MeSH
- králíci MeSH
- prasata MeSH
- skot MeSH
- těhotenství MeSH
- vývojová regulace genové exprese * MeSH
- zvířata MeSH
- zygota metabolismus ultrastruktura MeSH
- Check Tag
- králíci MeSH
- skot MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- chromatin MeSH
- histony MeSH
The pre-implantation period of mammalian development includes the formation of the zygote, the activation of the embryonic genome (EGA), and the beginning of cellular differentiation. During this period, protamines are replaced by histones, the methylated haploid parental genomes undergo demethylation following formation of the diploid zygote, and maternal control of development is succeeded by zygotic control. Superimposed on this activation of the embryonic genome is the formation of a chromatin-mediated transcriptionally repressive state requiring enhancers for efficient gene expression. The development of this transcriptionally repressive state most likely occurs at the level of chromatin structure, because inducing histone hyperacetylation relieves the requirements for enhancers. Characterization of zygotic mRNA expression patterns during the pre-implantation period and their relationship to successful development in vitro and in vivo will be essential for defining optimized culture conditions and nuclear transfer protocols. The focus of this review is to summarize recent advances in this field and to discuss their implications for developmental biology.
Citace poskytuje Crossref.org
The neglected part of early embryonic development: maternal protein degradation