The presented article studies the role of selected inflammatory and anti-inflammatory serum markers of psoriatic patients in the pathogenesis of metabolic syndrome (MS) and psoriasis. The study is based on the comparison between the group of psoriatic patients (74) and the control group (65). We found significantly higher BMI (p < 0.05) and diastolic blood pressure (p < 0.05) in the psoriatic patients. The values of waist circumference and BMI were significantly higher (p < 0.05) in the male patients compared to the men in the control group. The analysis revealed significantly higher CRP (p < 0.001), Lp-PLA2 (p < 0.001), leptin (p < 0.01), and resistin (p < 0.01) levels in the psoriatic patients. Significantly higher levels of CRP (p < 0.01), Lp-PLA2 (p < 0.001), leptin (p < 0.01), and resistin (p < 0.05) were found in the patients with MS compared to the controls with MS. The level of adiponectin was significantly lower (p < 0.01) in the patients with MS. Finally, we found significantly higher level of Lp-PLA2 (p < 0.001) in the group of patients without MS compared to the controls without MS. In conclusion, observed inflammatory and anti-inflammatory markers (CRP, adiponectin, leptin, resistin, and Lp-PLA2) are involved in both pathogenesis of MS and pathogenesis of psoriasis. The level of Lp-PLA2 indicates the presence of subclinical atherosclerosis (cardiovascular risk) in psoriatic patients.

• MeSH
• 1-Alkyl-2-acetylglycerophosphocholine Esterase blood   MeSH
• Adiponectin blood   MeSH
• Biomarkers blood   MeSH
• C-Reactive Protein metabolism   MeSH
• Adult MeSH
• Body Mass Index MeSH
• Blood Pressure MeSH
• Leptin blood   MeSH
• Middle Aged MeSH
• Humans MeSH
• Metabolic Syndrome blood   immunology   pathology   MeSH
• Adolescent MeSH
• Young Adult MeSH
• Waist Circumference MeSH
• Psoriasis blood   immunology   pathology   MeSH
• Resistin blood   MeSH
• Aged, 80 and over MeSH
• Aged MeSH
• Case-Control Studies MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Adolescent MeSH
• Young Adult MeSH
• Male MeSH
• Aged, 80 and over MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• 1-Alkyl-2-acetylglycerophosphocholine Esterase MeSH
• Adiponectin MeSH
• Biomarkers MeSH
• C-Reactive Protein MeSH
• Leptin MeSH
• Resistin MeSH

Psoriasis is associated with metabolic activity of adipose tissue which produces pro- and anti-inflammatory adipokines. Goeckerman therapy (GT) represents an effective treatment of psoriasis. This study evaluated variation of selected inflammatory and metabolic markers during GT and the relationships between the markers, severity of the disease (PASI score), body mass, and the basic characteristics of the therapy. The study was conducted on a group of patients (n = 32) and on a control group (n = 24). Before GT, we found significantly elevated levels of proinflammatory CRP (p < 0.001) and leptin (p < 0.05) in psoriatic patients (compared to the controls). The therapy significantly decreased the levels of CRP and adiponectin. We found positive correlations between CRP and total duration of GT (p < 0.05) and CRP and the time of UV exposure (p < 0.01) and negative correlations between adiponectin and the total duration of GT (p < 0.05) and adiponectin and the application of CCT ointment (p < 0.001). From our results, we can conclude that GT causes partial reduction of both proinflammatory and anti-inflammatory markers. However, the levels of proinflammatory CRP and leptin remained significantly higher in the patients than in the control group.

• MeSH
• Adiponectin blood   MeSH
• Biomarkers MeSH
• C-Reactive Protein analysis   MeSH
• Adult MeSH
• Body Mass Index MeSH
• Leptin blood   MeSH
• Middle Aged MeSH
• Humans MeSH
• Ointments MeSH
• Psoriasis blood   drug therapy   MeSH
• Aged MeSH
• Severity of Illness Index MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Names of Substances
• Adiponectin MeSH
• Biomarkers MeSH
• C-Reactive Protein MeSH
• Leptin MeSH
• Ointments MeSH

The paper presents a prospective cohort study. Observed group was formed of children with plaque psoriasis (n=19) treated by Goeckerman therapy (GT). The study describes adverse (side) effects associated with application of GT (combined exposure of 3% crude coal tar ointment and UV radiation). After GT we found significantly increased markers of oxidative stress (8-hydroxy-2'-deoxyguanosine, 8-hydroxyguanosine, and 8-hydroxyguanine), significantly increased levels of benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE) DNA adducts (BPDE-DNA), and significantly increased levels of total number of chromosomal aberrations in peripheral lymphocytes. We found significant relationship between (1) time of UV exposure and total number of aberrated cells and (2) daily topical application of 3% crude coal tar ointment (% of body surface) and level of BPDE-DNA adducts. The findings indicated increased hazard of oxidative stress and genotoxic effects related to the treatment. However, it must be noted that the oxidized guanine species and BPDE-DNA adducts also reflect individual variations in metabolic enzyme activity (different extent of bioactivation of benzo[a]pyrene to BPDE) and overall efficiency of DNA/RNA repair system. The study confirmed good effectiveness of the GT (significantly decreased PASI score).

• MeSH
• 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide analysis   chemistry   MeSH
• DNA Adducts analysis   chemistry   MeSH
• Benzo(a)pyrene chemistry   toxicity   MeSH
• Chromosome Aberrations * MeSH
• Coal Tar pharmacology   therapeutic use   MeSH
• Child MeSH
• DNA chemistry   MeSH
• Keratolytic Agents pharmacology   therapeutic use   MeSH
• Cohort Studies MeSH
• Humans MeSH
• Lymphocytes cytology   metabolism   MeSH
• Ointments pharmacology   therapeutic use   MeSH
• Adolescent MeSH
• Oxidative Stress drug effects   MeSH
• DNA Damage drug effects   MeSH
• Child, Preschool MeSH
• Prospective Studies MeSH
• Psoriasis drug therapy   metabolism   pathology   MeSH
• Ultraviolet Rays * MeSH
• Check Tag
• Child MeSH
• Humans MeSH
• Adolescent MeSH
• Male MeSH
• Child, Preschool MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Names of Substances
• 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide MeSH
• DNA Adducts MeSH
• benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA MeSH Browser
• Benzo(a)pyrene MeSH
• Coal Tar MeSH
• DNA MeSH
• Keratolytic Agents MeSH
• Ointments MeSH