Hop (Humulus lupulus L.), as a key ingredient for beer brewing, is also a source of many biologically active molecules. A notable compound, 8-prenylnaringenin (8-PN), structurally belonging to the group of prenylated flavonoids, was shown to be a potent phytoestrogen, and thus, became the topic of active research. Here, we overview the pharmacological properties of 8-PN and its therapeutic opportunities. Due to its estrogenic effects, administration of 8-PN represents a novel therapeutic approach to the treatment of menopausal and post-menopausal symptoms that occur as a consequence of a progressive decline in hormone levels in women. Application of 8-PN in the treatment of menopause has been clinically examined with promising results. Other activities that have already been assessed include the potential to prevent bone-resorption or inhibition of tumor growth. On the other hand, the use of phytoestrogens is frequently questioned regarding possible adverse effects associated with long-term consumption. In conclusion, we emphasize the implications of using 8-PN in future treatments of menopausal and post-menopausal symptoms, including the need for precise evidence and further investigations to define the safety risks related to its therapeutic use.

• Klíčová slova
• 8-prenylnaringenin, hops, menopause, phytoestrogens,
• MeSH
• flavanony škodlivé účinky   chemie   farmakologie   MeSH
• fytoestrogeny škodlivé účinky   chemie   farmakologie   MeSH
• fytogenní protinádorové látky škodlivé účinky   chemie   farmakologie   MeSH
• Humulus chemie   MeSH
• lidé MeSH
• menopauza účinky léků   MeSH
• molekulární struktura MeSH
• postmenopauzální osteoporóza farmakoterapie   MeSH
• Check Tag
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• 8-prenylnaringenin MeSH Prohlížeč
• flavanony MeSH
• fytoestrogeny MeSH
• fytogenní protinádorové látky MeSH

Historically, hop cones (Humulus lupulus) have been used since ancient times as a remedy for many ailments and, as a source of polyphenols and bitter acids, is very effective in the treatment of metabolic syndrome (MS). Hop flavonoids, particularly xanthohumol (XN), are substances with hypoglycemic, antihyperlipidemic, and antiobesity activities. Iso-α-acids (IAA) and matured hop bitter acids (MHBA) improve health by influencing lipid metabolism, glucose tolerance, and body weight. The modulatory effect of IAA and MHBA on lipid metabolism may also be responsible for a loss in body weight. These results suggest promising applications for IAA, MHBA, and XN in humans, particularly in the prevention of diet-induced obesity and diabetes.

• Klíčová slova
• cholesterol, diabetes, hops, iso-α-acids, matured hop bitter acids, metabolic syndrome, obesity, xanthohumol,
• MeSH
• flavonoidy chemie   farmakologie   terapeutické užití   MeSH
• fytonutrienty chemie   farmakologie   terapeutické užití   MeSH
• glukózový toleranční test MeSH
• Humulus chemie   MeSH
• lidé MeSH
• metabolický syndrom farmakoterapie   prevence a kontrola   MeSH
• metabolismus lipidů účinky léků   MeSH
• molekulární struktura MeSH
• propiofenony farmakologie   terapeutické užití   MeSH
• tělesná hmotnost účinky léků   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• flavonoidy MeSH
• fytonutrienty MeSH
• propiofenony MeSH
• xanthohumol MeSH Prohlížeč