Most cited article - PubMed ID 25918064
Effects of captopril, spironolactone, and simvastatin on the cardiovascular system of non-diseased Wistar rats
Current knowledge on the renin-angiotensin system (RAS) indicates its central role in the pathogenesis of cardiovascular remodelling via both hemodynamic alterations and direct growth and the proliferation effects of angiotensin II or aldosterone resulting in the hypertrophy of cardiomyocytes, the proliferation of fibroblasts, and inflammatory immune cell activation. The noncoding regulatory microRNAs has recently emerged as a completely novel approach to the study of the RAS. A growing number of microRNAs serve as mediators and/or regulators of RAS-induced cardiac remodelling by directly targeting RAS enzymes, receptors, signalling molecules, or inhibitors of signalling pathways. Specifically, microRNAs that directly modulate pro-hypertrophic, pro-fibrotic and pro-inflammatory signalling initiated by angiotensin II receptor type 1 (AT1R) stimulation are of particular relevance in mediating the cardiovascular effects of the RAS. The aim of this review is to summarize the current knowledge in the field that is still in the early stage of preclinical investigation with occasionally conflicting reports. Understanding the big picture of microRNAs not only aids in the improved understanding of cardiac response to injury but also leads to better therapeutic strategies utilizing microRNAs as biomarkers, therapeutic agents and pharmacological targets.
- Keywords
- RAS, cardiac fibrosis, cardiac hypertrophy, cardiac remodelling, miRNA,
- MeSH
- Fibrosis MeSH
- Cardiomegaly genetics metabolism pathology MeSH
- Humans MeSH
- MicroRNAs genetics metabolism MeSH
- Myocardium metabolism pathology MeSH
- Heart Diseases genetics metabolism pathology MeSH
- Renin-Angiotensin System * MeSH
- Signal Transduction * MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- MicroRNAs MeSH