BACKGROUND This study was carried out to determine the relationship between the common TMEM-18 (rs4854344, G>T) and NYD-SP18 (rs6971091, G>A) gene variants and weight loss after lifestyle interventions (increased physical activity in conjunction with optimal dietary intake) in overweight/obese children/adolescents. MATERIAL AND METHODS We genotyped 684 unrelated, white, non-diabetic children (age 12.7±2.1 years, average BMI at baseline 30.66±4.80 kg/m²). Anthropometric and biochemical examinations were performed before and after 4 weeks of an intensive lifestyle intervention. RESULTS The mean weight loss achieved was 5.20±2.02 kg (P<0.001). NYDSP-18 AA homozygotes had significantly higher abdominal skinfold value before and after the intervention (both, P=0.001). No significant associations between BMI decrease and the NYD-SP18 and TMEM18 variants were found. Associations between all anthropometrical and biochemical changes and genes remained non-significant after data were adjusted for sex, age, and baseline values. CONCLUSIONS Decreased body weight in overweight/obese children is not significantly influenced by the NYD-SP18 rs6971091 or TMEM18 rs4854344 polymorphisms.

• MeSH
• adipozita genetika   MeSH
• cvičení MeSH
• dítě MeSH
• genotyp MeSH
• hmotnostní úbytek genetika   MeSH
• index tělesné hmotnosti MeSH
• jaderné proteiny genetika   metabolismus   MeSH
• jednonukleotidový polymorfismus MeSH
• lidé MeSH
• membránové proteiny genetika   metabolismus   MeSH
• mladiství MeSH
• nadváha genetika   MeSH
• obezita genetika   MeSH
• tělesná hmotnost genetika   MeSH
• životní styl MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• FAM71F1 protein, human MeSH Prohlížeč
• jaderné proteiny MeSH
• membránové proteiny MeSH
• TMEM18 protein, human MeSH Prohlížeč