Most cited article - PubMed ID 29429912
Denosumab versus zoledronic acid in bone disease treatment of newly diagnosed multiple myeloma: an international, double-blind, double-dummy, randomised, controlled, phase 3 study
Multiple myeloma (MM) is a hematological malignancy caused by the clonal expansion of plasma cells. The incidence of MM worldwide is increasing with greater than 140 000 people being diagnosed with MM per year. Whereas 5-year survival after a diagnosis of MM has improved from 28% in 1975 to 56% in 2012, the disease remains essentially incurable. In this review, we summarize our current understanding of MM including its epidemiology, genetics and biology. We will also provide an overview of MM management that has led to improvements in survival, including recent changes to diagnosis and therapies. Areas of unmet need include the management of patients with high-risk MM, those with reduced performance status and those refractory to standard therapies. Ongoing research into the biology and early detection of MM as well as the development of novel therapies, such as immunotherapies, has the potential to influence MM practice in the future.
- Keywords
- clinical presentation, plasma cell disease, risks factors, survival, treatment,
- MeSH
- Cyclin D1 genetics MeSH
- Exosome Multienzyme Ribonuclease Complex genetics MeSH
- Genetic Predisposition to Disease MeSH
- Histone Demethylases genetics MeSH
- Immunotherapy methods MeSH
- Humans MeSH
- Survival Rate MeSH
- Multiple Myeloma diagnosis epidemiology genetics therapy MeSH
- Mutation MeSH
- Biomarkers, Tumor genetics MeSH
- Plasma Cells immunology pathology MeSH
- Repressor Proteins genetics MeSH
- Risk Factors MeSH
- Transcriptional Elongation Factors genetics MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- CCND1 protein, human MeSH Browser
- CDCA7L protein, human MeSH Browser
- Cyclin D1 MeSH
- DIS3 protein, human MeSH Browser
- ELL2 protein, human MeSH Browser
- Exosome Multienzyme Ribonuclease Complex MeSH
- Histone Demethylases MeSH
- KDM1A protein, human MeSH Browser
- Biomarkers, Tumor MeSH
- Repressor Proteins MeSH
- Transcriptional Elongation Factors MeSH
