Diabetic foot is a serious late complication frequently caused by infection and ischaemia. Both require prompt and aggressive treatment to avoid lower limb amputation. The effectiveness of peripheral arterial disease therapy can be easily verified using triplex ultrasound, ankle-brachial/toe-brachial index examination, or transcutaneous oxygen pressure. However, the success of infection treatment is difficult to establish in patients with diabetic foot. Intravenous systemic antibiotics are recommended for the treatment of infectious complications in patients with moderate or serious stages of infection. Antibiotic therapy should be initiated promptly and aggressively to achieve sufficient serum and peripheral antibiotic concentrations. Antibiotic serum levels are easily evaluated by pharmacokinetic assessment. However, antibiotic concentrations in peripheral tissues, especially in diabetic foot, are not routinely detectable. This review describes microdialysis techniques that have shown promise in determining antibiotic levels in the surroundings of diabetic foot lesions.

• Keywords
• antibiotic (ATB), capillary electrophoresis (CE), diabetic foot (DF), diabetic foot infection (DFI), microdialysis (MD),
• MeSH
• Amputation, Surgical MeSH
• Anti-Bacterial Agents therapeutic use   MeSH
• Diabetes Mellitus * drug therapy   MeSH
• Diabetic Foot * diagnosis   drug therapy   MeSH
• Lower Extremity pathology   MeSH
• Humans MeSH
• Microdialysis adverse effects   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Review MeSH
• Names of Substances
• Anti-Bacterial Agents MeSH