Mantle cell lymphoma (MCL) is a heterogeneous malignancy with a broad spectrum of clinical behavior from indolent to highly aggressive cases. Despite the fact that MCL remains in most cases incurable by currently applied immunochemotherapy, our increasing knowledge on the biology of MCL in the last two decades has led to the design, testing, and approval of several innovative agents that dramatically changed the treatment landscape for MCL patients. Most importantly, the implementation of new drugs and novel treatment algorithms into clinical practice has successfully translated into improved outcomes of MCL patients not only in the clinical trials, but also in real life. This review focuses on recent advances in our understanding of the pathogenesis of MCL, and provides a brief survey of currently used treatment options with special focus on mode of action of selected innovative anti-lymphoma molecules. Finally, it outlines future perspectives of patient management with progressive shift from generally applied immunotherapy toward risk-stratified, patient-tailored protocols that would implement innovative agents and/or procedures with the ultimate goal to eradicate the lymphoma and cure the patient.

• Keywords
• B-cell receptor signaling, cell cycle, mantle cell lymphoma,
• MeSH
• Cell Cycle drug effects   genetics   MeSH
• Drug Resistance, Neoplasm MeSH
• Molecular Targeted Therapy * methods   MeSH
• Genetic Variation MeSH
• Clonal Evolution drug effects   genetics   MeSH
• Combined Modality Therapy MeSH
• Humans MeSH
• Lymphoma, Mantle-Cell drug therapy   etiology   metabolism   mortality   MeSH
• Disease Susceptibility MeSH
• Biomarkers, Tumor antagonists & inhibitors   MeSH
• Prognosis MeSH
• Antineoplastic Agents pharmacology   therapeutic use   MeSH
• Receptors, Antigen, B-Cell metabolism   MeSH
• Recurrence MeSH
• Gene Expression Regulation, Neoplastic drug effects   MeSH
• Signal Transduction drug effects   MeSH
• Treatment Outcome MeSH
• Animals MeSH
• Check Tag
• Humans MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Review MeSH
• Names of Substances
• Biomarkers, Tumor MeSH
• Antineoplastic Agents MeSH
• Receptors, Antigen, B-Cell MeSH