Most cited article - PubMed ID 30538471
Safe decontamination of cytostatics from the nitrogen mustards family. Part one: cyclophosphamide and ifosfamide
Anthracyclines are a class of pharmaceuticals used in cancer treatment have the potential to negatively impact the environment. To study the possibilities of anthracyclines (represented by pirarubicin and valrubicin) removal, chemical inactivation using NaOH (0.01 M) and NaClO (5%) as decontamination agents and adsorption to powdered nanocrystalline titanium dioxide (TiO2) were compared. The titanium dioxide (TiO2) nanoparticles were prepared via homogeneous precipitation of an aqueous solution of titanium (IV) oxy-sulfate (TiOSO4) at different amount (5-120 g) with urea. The as-prepared TiO2 samples were characterized by XRD, HRSEM and nitrogen physisorption. The adsorption process of anthracycline cytostatics was determined followed by high-performance liquid chromatography coupled with mass spectrometry (LC-MS) and an in-situ Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS) technique. It was found that NaClO decomposes anthracyclines to form various transformation products (TPs). No TPs were identified after the reaction of valrubicin with a NaOH solution as well as in the presence of TiO2 nanoparticles. The best degree of removal, 100% of pirarubicin and 85% of valrubicin, has been achieved in a sample with 120 grams of TiOSO4 (TIT120) and TiO2 with 60 grams (TIT60), respectively.
- MeSH
- Adsorption MeSH
- Water Pollutants, Chemical chemistry isolation & purification MeSH
- Sodium Hypochlorite chemistry MeSH
- Cytostatic Agents chemistry isolation & purification MeSH
- Decontamination methods MeSH
- Doxorubicin analogs & derivatives chemistry isolation & purification MeSH
- Hydrolysis MeSH
- Sodium Hydroxide chemistry MeSH
- Crystallization MeSH
- Nanostructures chemistry MeSH
- Surface Properties MeSH
- Titanium chemistry MeSH
- Particle Size MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Names of Substances
- Water Pollutants, Chemical MeSH
- Sodium Hypochlorite MeSH
- Cytostatic Agents MeSH
- Doxorubicin MeSH
- Sodium Hydroxide MeSH
- pirarubicin MeSH Browser
- Titanium MeSH
- titanium dioxide MeSH Browser
- valrubicin MeSH Browser
