Hyaluronic acid (HA) is an acidic, non-sulfated glycosaminoglycan that is intensively studied as a biodegradable and biocompatible material for scaffolding, regenerative medicine, and clinical applications [...].

• MeSH
• Biocompatible Materials * therapeutic use   MeSH
• Hyaluronic Acid * MeSH
• Humans MeSH
• Regenerative Medicine MeSH
• Check Tag
• Humans MeSH
• Publication type
• Editorial MeSH
• Names of Substances
• Biocompatible Materials * MeSH
• Hyaluronic Acid * MeSH

Alveolar osteitis (AO) is a common complication following the extraction of the teeth, particularly the lower third molars. It starts within a few days after the extraction and manifests mainly as pain in the extraction site. Several strategies of treatment are available in order to relieve pain and heal the extraction wound. Recently, a novel medical device combining hyaluronic acid (HA) and octenidine (OCT) was introduced for the treatment of AO. This series of case reports aims to summarize the initial clinical experiences with this new device and to highlight factors possibly interfering with this treatment. The medical documentation of five patients with similar initial situations treated for AO with HA + OCT device was analyzed in detail. Smoking and previous treatment with Alveogyl (Septodont, Saint-Maur-des-Fossés, France) were identified as factors interfering with the AO treatment with the HA + OCT device. In three patients without these risk factors, the treatment led to recovery within two or three days. The patient pretreated with Alveogyl and the smoker required six and seven applications of the HA + OCT device, respectively. According to these initial observations, it seems smoking and previous treatment with Alveogyl prolong the treatment of AO using the HA + OCT device that, in turn, shows a rapid effect if these risk factors are not present.

• Keywords
• Alveolar osteitis, hyaluronic acid, octenidine, risk factors, smoking, treatment effectivity, wound healing,
• MeSH
• Pain drug therapy   etiology   physiopathology   surgery   MeSH
• Adult MeSH
• Tooth Extraction adverse effects   MeSH
• Drug Combinations MeSH
• Wound Healing drug effects   physiology   MeSH
• Imines therapeutic use   MeSH
• Hydrocarbons, Iodinated adverse effects   MeSH
• Smoking adverse effects   MeSH
• Creosote adverse effects   MeSH
• Hyaluronic Acid therapeutic use   MeSH
• Middle Aged MeSH
• Humans MeSH
• Adolescent MeSH
• Molar surgery   MeSH
• Dry Socket drug therapy   etiology   physiopathology   surgery   MeSH
• Pyridines therapeutic use   MeSH
• Risk Factors MeSH
• Thymol MeSH
• Treatment Outcome MeSH
• Equipment and Supplies MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Adolescent MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Case Reports MeSH
• Research Support, Non-U.S. Gov't MeSH
• Names of Substances
• Drug Combinations MeSH
• Imines MeSH
• Hydrocarbons, Iodinated MeSH
• Creosote MeSH
• Hyaluronic Acid MeSH
• octenidine MeSH Browser
• Pyridines MeSH
• Septodont MeSH Browser
• Thymol MeSH