4-methylumbelliferone (4MU) has been suggested as a potential therapeutic agent for a wide range of neurological diseases. The current study aimed to evaluate the physiological changes and potential side effects after 10 weeks of 4MU treatment at a dose of 1.2 g/kg/day in healthy rats, and after 2 months of a wash-out period. Our findings revealed downregulation of hyaluronan (HA) and chondroitin sulphate proteoglycans throughout the body, significantly increased bile acids in blood samples in weeks 4 and 7 of the 4MU treatment, as well as increased blood sugars and proteins a few weeks after 4MU administration, and significantly increased interleukins IL10, IL12p70 and IFN gamma after 10 weeks of 4MU treatment. These effects, however, were reversed and no significant difference was observed between control treated and 4MU-treated animals after a 9-week wash-out period.

• Klíčová slova
• 4-methylumbelliferone, chondroitin sulphates, hyaluronan, neuroplasticity,
• MeSH
• hymekromon * škodlivé účinky   terapeutické užití   MeSH
• interleukin-12 MeSH
• krysa rodu Rattus MeSH
• kyselina hyaluronová * metabolismus   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• hymekromon * MeSH
• interleukin-12 MeSH
• kyselina hyaluronová * MeSH

Alveolar osteitis (AO) is a common complication following the extraction of the teeth, particularly the lower third molars. It starts within a few days after the extraction and manifests mainly as pain in the extraction site. Several strategies of treatment are available in order to relieve pain and heal the extraction wound. Recently, a novel medical device combining hyaluronic acid (HA) and octenidine (OCT) was introduced for the treatment of AO. This series of case reports aims to summarize the initial clinical experiences with this new device and to highlight factors possibly interfering with this treatment. The medical documentation of five patients with similar initial situations treated for AO with HA + OCT device was analyzed in detail. Smoking and previous treatment with Alveogyl (Septodont, Saint-Maur-des-Fossés, France) were identified as factors interfering with the AO treatment with the HA + OCT device. In three patients without these risk factors, the treatment led to recovery within two or three days. The patient pretreated with Alveogyl and the smoker required six and seven applications of the HA + OCT device, respectively. According to these initial observations, it seems smoking and previous treatment with Alveogyl prolong the treatment of AO using the HA + OCT device that, in turn, shows a rapid effect if these risk factors are not present.

• Klíčová slova
• Alveolar osteitis, hyaluronic acid, octenidine, risk factors, smoking, treatment effectivity, wound healing,
• MeSH
• bolest farmakoterapie   etiologie   patofyziologie   chirurgie   MeSH
• dospělí MeSH
• extrakce zubů škodlivé účinky   MeSH
• fixní kombinace léků MeSH
• hojení ran účinky léků   fyziologie   MeSH
• iminy terapeutické užití   MeSH
• jodované uhlovodíky škodlivé účinky   MeSH
• kouření škodlivé účinky   MeSH
• kreosot škodlivé účinky   MeSH
• kyselina hyaluronová terapeutické užití   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• moláry chirurgie   MeSH
• poextrakční zánět zubního lůžka farmakoterapie   etiologie   patofyziologie   chirurgie   MeSH
• pyridiny terapeutické užití   MeSH
• rizikové faktory MeSH
• thymol MeSH
• výsledek terapie MeSH
• zdravotnické prostředky MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• práce podpořená grantem MeSH
• Názvy látek
• fixní kombinace léků MeSH
• iminy MeSH
• jodované uhlovodíky MeSH
• kreosot MeSH
• kyselina hyaluronová MeSH
• octenidine MeSH Prohlížeč
• pyridiny MeSH
• Septodont MeSH Prohlížeč
• thymol MeSH

Alveolar Osteitis (AO) is a complication following the extraction of a tooth. AO manifests through localized pain in, and around, the extraction site, where the post-operative blood clot has been disintegrated. The aim of this single cohort study was to evaluate the outcome of a treatment of AO, using a pharmacological device composed of hyaluronic acid and octenidine dihydrochloride. The tested device is a sponge-like material, composed solely of a fully dissoluble medicaments (hyaluronic acid, calcium chloride, and octenidine dihydrochloride). It was designed to serve as a non-toxic, slow-dissolving antiseptic, that adheres to mucosa and obturates the wound. This study includes 58 subjects who were diagnosed with AO. The tested device was administered once daily until local pain subsided to < 20 mm of the Visual Analog Scale (VAS). The treatment was considered effective when the pain subsided to < 20 mm VAS in < 8 days of treatment; as per comparative studies. Our findings provide a statistically significant success rate of 96.0% (95.0% confidence interval of 75.75% to 97.8%) after pharmacological device administrations. No adverse medical effects were detected. Acquired data confirmed that lyophilized hyaluronic acid, combined with octenidine, is effective for the treatment of AO. The results are clinically important as AO is a common complication after third molar extractions.

• Klíčová slova
• alveolalgia, alveolar osteitis, alveolitis sicca dolorosa, clinical study, first-in-man study, octenidine dihydrochloride, sodium hyaluronate,
• MeSH
• antiinfekční látky lokální aplikace a dávkování   terapeutické užití   MeSH
• dospělí MeSH
• extrakce zubů škodlivé účinky   MeSH
• iminy MeSH
• kohortové studie MeSH
• kyselina hyaluronová aplikace a dávkování   terapeutické užití   MeSH
• lidé středního věku MeSH
• lidé MeSH
• poextrakční zánět zubního lůžka farmakoterapie   MeSH
• pyridiny aplikace a dávkování   terapeutické užití   MeSH
• vstřebatelné implantáty MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• klinické zkoušky MeSH
• multicentrická studie MeSH
• práce podpořená grantem MeSH
• Názvy látek
• antiinfekční látky lokální MeSH
• iminy MeSH
• kyselina hyaluronová MeSH
• octenidine MeSH Prohlížeč
• pyridiny MeSH