Mitral valve prolapse (MVP) belongs to cardiac disorders characterized by impaired closure of mitral leaflets. We studied adolescent group of patients with MVP suffering from symptomatology that cannot be explained by mitral regurgitation alone. Several studies suggested that symptoms can be explained by autonomic, in particular sympathetic-linked dysfunction. Thus, we assessed non-invasive sympathetic indices of blood pressure and heart rate variability and electrodermal activity (EDA). Fifty-three adolescents with MVP (age: 15.1+/-0.4 years) and 43 healthy age- and gender-matched adolescents (age: 14.9+/-0.4 years) were examined. Blood pressure, heart rate and EDA were continuously recorded during 6-min rest. Evaluated parameters were: low frequency band of systolic blood pressure variability, systolic, diastolic and mean blood pressure, mean RR interval, cardiac sympathetic indices: symbolic dynamics (0V%), left ventricular ejection time (LVET), pre-ejection period (PEP), and EDA. Our findings revealed significantly higher systolic, diastolic, and mean blood pressure values, shortened mean RR interval, increased 0V%, and shortened LVET in MVP patients vs. controls (p=0.028, p<0.001, p=0.002, p<0.001, p=0.050, p<0.001; respectively). Our study revealed enhanced cardiovascular sympathetic regulation in adolescent MVP patients. We suggest that evaluation of non-invasive sympathetic parameters could represent potential biomarkers for early diagnosis of cardiovascular complications associated with MVP already at adolescent age.

• MeSH
• funkce levé komory srdeční MeSH
• galvanická kožní odpověď MeSH
• krevní tlak MeSH
• lidé MeSH
• mitrální insuficience diagnóza   patofyziologie   MeSH
• mladiství MeSH
• prognóza MeSH
• prolaps mitrální chlopně diagnóza   patofyziologie   MeSH
• srdce diagnostické zobrazování   inervace   MeSH
• srdeční frekvence MeSH
• studie případů a kontrol MeSH
• sympatický nervový systém patofyziologie   MeSH
• věkové faktory MeSH
• Check Tag
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

Human health is the main role of medical research. Scientists were always intrigued by disease prevention, their diagnostics and proper treatment. In fact, research in medicine is always directed towards the improvement of the health care and improvement of the quality of life of the target population. Nowadays, physiological research, which is the base stone for clinical research, progresses fast forward, providing new information about body functions in health and diseases. This obvious progress is associated with modern methods, such as neuronal tracing, patch-clamp methods, electrophysiology, molecular biology and many more, which supported by comprehensive information technology guarantees high quality and complex data. Our younger colleagues, young scientists, post-docs or PhD students are well-trained and qualified in utilizing these new methods.

• MeSH
• akademický sbor lékařské fakulty dějiny   MeSH
• biomedicínský výzkum dějiny   MeSH
• dějiny 20. století MeSH
• dějiny 21. století MeSH
• internacionalita MeSH
• lékaři dějiny   MeSH
• lidé MeSH
• mechanika dýchání fyziologie   MeSH
• poruchy dýchání dějiny   patofyziologie   MeSH
• Check Tag
• dějiny 20. století MeSH
• dějiny 21. století MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• biografie MeSH
• historické články MeSH
• úvodníky MeSH
• Geografické názvy
• Slovenská republika MeSH

• O autorovi
• Korpas, Juraj