Substances studied at this department in 1954-1983 are reviewed; a total of 226 compounds are characterized in a tabular form. They include natural compounds as well as those prepared by biotransformation, by semisynthetic and synthetic methods.

• MeSH
• antibakteriální látky izolace a purifikace   MeSH
• mikrobiologie MeSH
• organická chemie * MeSH
• pojmy organické chemie MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• antibakteriální látky MeSH

Mutants of Streptomyces coeruleorubidus, blocked in the biosynthesis of anthracycline antibiotics of the daunomycine complex, were isolated from the production strains after treatment with UV light, gamma-radiation, nitrous acid, and after natural selection; according to their different biosynthetic activity the mutants were divided into five phenotypic groups. Mutants of two of these groups produced compounds that had not yet been described in Streptomyces coeruleorubidus (aklavinone, 7-deoxyaklavinone, zeta-rhodomycinone and glycosides of epsilon-rhodomycinone). The mutants differed from the parent strains and also mutually in morphological characteristics but no direct correlation between these changes and the biosynthetic activity could be observed in most cases.

• MeSH
• anthrachinony biosyntéza   MeSH
• daunomycin biosyntéza   MeSH
• glykosidy biosyntéza   MeSH
• mutace MeSH
• Streptomyces cytologie   genetika   metabolismus   MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• anthrachinony MeSH
• daunomycin MeSH
• glykosidy MeSH

The production of epsilon-pyrromycinone glycosides in Streptomyces galilaeus increased 12-fold, with respect to the wild strain, as a result of a sequential procedure including both natural selection and treatment with mutagens (nitrous acid, UV light and gamma-irradiation). Nitrous acid exhibited the highest mutagenic effect, both in increasing the productivity and in inducing blocked mutants. A mutant strain blocked in the biosynthesis of glycosides and accumulating free epsilon-pyrromycinone as the principal metabolite was obtained.

• MeSH
• anthrachinony biosyntéza   MeSH
• glykosidy biosyntéza   MeSH
• kyselina dusitá farmakologie   MeSH
• mutace účinky léků   účinky záření   MeSH
• protinádorová antibiotika biosyntéza   MeSH
• Streptomyces účinky léků   genetika   metabolismus   účinky záření   MeSH
• ultrafialové záření MeSH
• záření gama MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• anthrachinony MeSH
• glykosidy MeSH
• kyselina dusitá MeSH
• protinádorová antibiotika MeSH