Methamphetamine (MA), as massively abused psychoactive stimulant, has been associated with many neurological diseases. It has various potent and neurotoxic properties. There are many mechanisms of action that contribute to its neurotoxic and degenerative effects, including excessive neurotransmitter (NEU) release, blockage of NEU uptake transporters, degeneration of NEU receptors, process of oxidative stress etc. MA intoxication is caused by blood-brain barrier disruption resulted from MA-induced oxidation stress. In our laboratory we constantly work on animal research of MA. Our current interest is to investigate processes of MA-induced alteration in neurotransmission, especially during development of laboratory rat. This review will describe current understanding in role of NEUs, which are affected by MA-induced neurotoxicity caused by altering the action of NEUs in the central nervous system (CNS). It also briefly brings information about NEUs development in critical periods of development.

• MeSH
• Central Nervous System drug effects   growth & development   metabolism   MeSH
• Behavior, Animal drug effects   MeSH
• Rats MeSH
• Humans MeSH
• Methamphetamine toxicity   MeSH
• Synaptic Transmission drug effects   MeSH
• Neurogenesis drug effects   MeSH
• Neurotoxicity Syndromes etiology   metabolism   pathology   MeSH
• Neurotransmitter Agents toxicity   MeSH
• Central Nervous System Stimulants toxicity   MeSH
• Animals MeSH
• Check Tag
• Rats MeSH
• Humans MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Review MeSH
• Names of Substances
• Methamphetamine MeSH
• Neurotransmitter Agents MeSH
• Central Nervous System Stimulants MeSH