In the rat model, 6-hydroxydopamine (6-OHDA) known as a selective catecholaminergic neurotoxin used chiefly in modeling Parkinson's disease (PD). Continuous aerobic exercise and curcumin supplementations could play a vital role in neuroprotection. This study aimed to explore the neuroprotective roles of regular aerobic exercise and curcumin during PD. For this, rats were treated as follows for 8 consecutive weeks (5 d in a week): For this, animals were orally treated with curcumin (50 ml/kg) alone or in combination with aerobic exercise. Compared with a control group, induction of PD by 6-OHDA increased the amount of alpha-synuclein protein and malondialdehyde levels and decreased the number of substantia nigra neurons, total antioxidant capacity, and glutathione peroxidase activity in brain tissue. All these changes were abolished by the administration of curcumin with aerobic exercise treatments. Activity behavioral tests also confirmed the above-mentioned results by increasing the rod test time and the number of rotations due to apomorphine injection. Histopathology assays mimic the antioxidant activity and behavioral observations. Combined curcumin with aerobic exercise treatments is potentially an effective strategy for modifying the dopaminergic neuron dysfunction in 6-OHDA-induced rats modeling PD via dual inhibiting oxidative stress indices and regulating behavioral tasks.

• MeSH
• alfa-synuklein metabolismus   MeSH
• antioxidancia metabolismus   farmakologie   MeSH
• apomorfin metabolismus   farmakologie   MeSH
• glutathionperoxidasa metabolismus   MeSH
• krysa rodu Rattus MeSH
• kurkumin * metabolismus   farmakologie   MeSH
• malondialdehyd MeSH
• modely nemocí na zvířatech MeSH
• neuroprotektivní látky * farmakologie   MeSH
• neurotoxické syndromy * MeSH
• neurotoxiny metabolismus   farmakologie   MeSH
• oxidopamin toxicita   MeSH
• Parkinsonova nemoc * farmakoterapie   metabolismus   MeSH
• substantia nigra MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• alfa-synuklein MeSH
• antioxidancia MeSH
• apomorfin MeSH
• glutathionperoxidasa MeSH
• kurkumin * MeSH
• malondialdehyd MeSH
• neuroprotektivní látky * MeSH
• neurotoxiny MeSH
• oxidopamin MeSH