Most cited article - PubMed ID 34313298
ESC working group on cardiac cellular electrophysiology position paper: relevance, opportunities, and limitations of experimental models for cardiac electrophysiology research
- MeSH
- Brugada Syndrome * physiopathology genetics diagnosis therapy MeSH
- Humans MeSH
- Disease Models, Animal * MeSH
- Mice MeSH
- NAV1.5 Voltage-Gated Sodium Channel genetics MeSH
- Sodium Channels genetics MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Comment MeSH
- Editorial MeSH
- Names of Substances
- NAV1.5 Voltage-Gated Sodium Channel MeSH
- Sodium Channels MeSH
Infectious diseases, which often result in deadly sepsis or septic shock, represent a major global health problem. For understanding the pathophysiology of sepsis and developing new treatment strategies, reliable and clinically relevant animal models of the disease are necessary. In this review, two large animal (porcine) models of sepsis induced by either peritonitis or bacteremia are introduced and their strong and weak points are discussed in the context of clinical relevance and other animal models of sepsis, with a special focus on cardiovascular and immune systems, experimental design, and monitoring. Especially for testing new therapeutic strategies, the large animal (porcine) models represent a more clinically relevant alternative to small animal models, and the findings obtained in small animal (transgenic) models should be verified in these clinically relevant large animal models before translation to the clinical level.
- Keywords
- SOFA score, bacteremia, cardiovascular system, immune system, large animal models, peritonitis, pig, sepsis,
- Publication type
- Journal Article MeSH
- Review MeSH
