Ulcerative colitis (UC) is a chronic inflammatory bowel disorder. Currently, the global incidence of UC has significantly increased. Traditional treatment methods are relatively limited, with generally poor efficacy and many side effects. In contrast, acupuncture holds great promise due to its significant efficacy, reduced relapse rate, and minimal side effects. In recent years, basic research on acupuncture treatment for UC has achieved substantial progress. However, the specific targets and pathways involved are still unclear. Therefore, this review aims to summarize and consolidate the mechanisms of acupuncture and acupuncture combined with drug therapy for UC. We primarily review the mechanisms of acupuncture treatment for UC from two aspects: intestinal inflammation and intestinal barrier. In terms of intestinal inflammation, acupuncture improves UC by regulating various inflammatory molecules such as TNF-alpha, IL-1beta, IL-10, NF-kappaB, and immune cells such as neutrophils, Th1, Th2, Treg, Th17. Concerning the intestinal barrier, we focus on the impact of acupuncture on the damage to intestinal epithelial cells (IECs). Moreover, acupuncture also possesses the capacity to reshape the gut microbiota, thereby repairing the biological barrier. Furthermore, the combination of acupuncture and medication for treating UC is a promising direction, which requires further exploration by researchers. This review thoroughly explains the molecular mechanisms of acupuncture in treating UC, establishing a foundation for further research on the effectiveness of acupuncture in UC treatment and offering a new perspective on the combination of acupuncture and medication. Key words Acupuncture " Electroacupuncture " Ulcerative colitis " Intestinal inflammation " Intestinal barrier.

• MeSH
• akupunkturní terapie * metody   MeSH
• kombinovaná terapie MeSH
• lidé MeSH
• ulcerózní kolitida * terapie   metabolismus   imunologie   MeSH
• výsledek terapie MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

BACKGROUND: Adipose tissue is significantly involved in inflammatory bowel disease (IBD). Vitamin D can affect both adipogenesis and inflammation. The aim of this study was to compare the production of selected adipokines, potentially involved in the pathogenesis of IBD - adiponectin, resistin, retinol binding protein 4 (RBP-4), adipocyte fatty acid binding protein and nesfatin-1 in children with IBD according to the presence of 25-hydroxyvitamin D (25(OH)D) deficiency. METHODS: The study was conducted as a case-control study in pediatric patients with IBD and healthy children of the same sex and age. In addition to adipokines and 25(OH)D, anthropometric parameters, markers of inflammation and disease activity were assessed in all participants. RESULTS: Children with IBD had significantly higher resistin levels regardless of 25(OH)D levels. IBD patients with 25(OH)D deficiency only had significantly lower RBP-4 compared to healthy controls and also compared to IBD patients without 25(OH)D deficiency. No other significant differences in adipokines were found in children with IBD with or without 25(OH)D deficiency. 25(OH)D levels in IBD patients corelated with RBP-4 only, and did not correlate with other adipokines. CONCLUSIONS: Whether the lower RBP-4 levels in the 25(OH)D-deficient group of IBD patients directly reflect vitamin D deficiency remains uncertain. The production of other adipokines does not appear to be directly related to vitamin D deficiency.

• Klíčová slova
• 25-hydroxyvitamin D, Adipocyte fatty acid binding protein, Adiponectin, Inflammatory bowel disease, Nesfatin-1, Resistin, Retinol-binding protein 4,
• MeSH
• adipokiny * krev   MeSH
• adiponektin krev   nedostatek   MeSH
• biologické markery krev   MeSH
• dítě MeSH
• DNA vazebné proteiny krev   MeSH
• idiopatické střevní záněty krev   komplikace   MeSH
• lidé MeSH
• mladiství MeSH
• nedostatek vitaminu D * komplikace   krev   MeSH
• nukleobindiny krev   MeSH
• plazmatické proteiny vázající retinol metabolismus   analýza   MeSH
• proteiny vázající mastné kyseliny krev   MeSH
• proteiny vázající vápník krev   MeSH
• resistin krev   MeSH
• studie případů a kontrol MeSH
• vitamin D * krev   analogy a deriváty   MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• 25-hydroxyvitamin D MeSH Prohlížeč
• adipokiny * MeSH
• adiponektin MeSH
• biologické markery MeSH
• DNA vazebné proteiny MeSH
• FABP4 protein, human MeSH Prohlížeč
• NUCB2 protein, human MeSH Prohlížeč
• nukleobindiny MeSH
• plazmatické proteiny vázající retinol MeSH
• proteiny vázající mastné kyseliny MeSH
• proteiny vázající vápník MeSH
• RBP4 protein, human MeSH Prohlížeč
• resistin MeSH
• vitamin D * MeSH