Flaviviruses such as dengue virus (DENV), Zika virus (ZIKV), and yellow fever virus (YFV) are spread by mosquitoes and cause human disease and mortality in tropical areas. In contrast, Powassan virus (POWV), which causes severe neurologic illness, is a flavivirus transmitted by ticks in temperate regions of the Northern hemisphere. We find serologic neutralizing activity against POWV in individuals living in Mexico and Brazil. Monoclonal antibodies P002 and P003, which were derived from a resident of Mexico (where POWV is not reported), neutralize POWV lineage I by recognizing an epitope on the virus envelope domain III (EDIII) that is shared with a broad range of tick- and mosquito-borne flaviviruses. Our findings raise the possibility that POWV, or a flavivirus closely related to it, infects humans in the tropics.

• Klíčová slova
• CP: Immunology, antibodies, flaviviruses, tick diseases,
• MeSH
• epitopy imunologie   MeSH
• Flavivirus imunologie   MeSH
• klíšťata virologie   imunologie   MeSH
• lidé MeSH
• monoklonální protilátky imunologie   MeSH
• neutralizující protilátky * imunologie   MeSH
• protilátky virové imunologie   MeSH
• viry klíšťové encefalitidy imunologie   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Research Support, N.I.H., Extramural MeSH
• Geografické názvy
• Brazílie MeSH
• Mexiko MeSH
• Názvy látek
• epitopy MeSH
• monoklonální protilátky MeSH
• neutralizující protilátky * MeSH
• protilátky virové MeSH