Early surgical treatment of giant cell tumour of the bone has very good functional outcomes with a relatively low risk of local recurrence and metastatic spread.In case of a pathologic fracture, extraosseous extension, and tumor location in an anatomically difficult area, surgical treatment may represent a big challenge with an uncertain functional outcome.Our case report presents a 35-year-old patient with a delayed diagnosis of giant cell tumor of the proximal radius of the dominant limb, with pulmonary metastases. Following neoadjuvant Denosumab therapy, with a major treatment effect on both the primary tumor and pulmonary metastases, we performed a wide resection and combined biological reconstruction with fibular autograft, radial head endoprosthesis, and comprehensive elbow ligament reconstruction.At 24 months after surgery, the patient is self-sufficient, capable of more physically demanding work, with a satisfactory functional outcome of reconstruction (MSTS 66.6%, TESS 69%), with no signs of local recurrence and regression of pulmonary metastases at 18 months after the last administration of Denosumab.

• Klíčová slova
• Denosumab, biological reconstruction., giant cell tumor of the bone, proximal radius, wide resection,
• MeSH
• denosumab terapeutické užití   MeSH
• dospělí MeSH
• fibula transplantace   MeSH
• inhibitory kostní resorpce terapeutické užití   MeSH
• lidé MeSH
• nádory kostí * chirurgie   patologie   farmakoterapie   MeSH
• nádory plic * sekundární   farmakoterapie   MeSH
• obrovskobuněčný nádor kosti * chirurgie   farmakoterapie   sekundární   patologie   MeSH
• radius * chirurgie   patologie   diagnostické zobrazování   MeSH
• transplantace kostí metody   MeSH
• výsledek terapie MeSH
• zákroky plastické chirurgie * metody   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• denosumab MeSH
• inhibitory kostní resorpce MeSH