Combined Proximal Radius Reconstruction Following Resection for Oncological Indication
Jazyk čeština Země Česko Médium print
Typ dokumentu kazuistiky, anglický abstrakt, časopisecké články
PubMed
40145589
DOI
10.55095/achot2024/068
- Klíčová slova
- Denosumab, biological reconstruction., giant cell tumor of the bone, proximal radius, wide resection,
- MeSH
- denosumab terapeutické užití MeSH
- dospělí MeSH
- fibula transplantace chirurgie MeSH
- inhibitory kostní resorpce terapeutické užití MeSH
- lidé MeSH
- nádory kostí * chirurgie sekundární MeSH
- nádory plic * chirurgie sekundární MeSH
- obrovskobuněčný nádor kosti * chirurgie MeSH
- radius * chirurgie MeSH
- transplantace kostí metody MeSH
- zákroky plastické chirurgie * metody MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- kazuistiky MeSH
- Názvy látek
- denosumab MeSH
- inhibitory kostní resorpce MeSH
Early surgical treatment of giant cell tumour of the bone has very good functional outcomes with a relatively low risk of local recurrence and metastatic spread.In case of a pathologic fracture, extraosseous extension, and tumor location in an anatomically difficult area, surgical treatment may represent a big challenge with an uncertain functional outcome.Our case report presents a 35-year-old patient with a delayed diagnosis of giant cell tumor of the proximal radius of the dominant limb, with pulmonary metastases. Following neoadjuvant Denosumab therapy, with a major treatment effect on both the primary tumor and pulmonary metastases, we performed a wide resection and combined biological reconstruction with fibular autograft, radial head endoprosthesis, and comprehensive elbow ligament reconstruction.At 24 months after surgery, the patient is self-sufficient, capable of more physically demanding work, with a satisfactory functional outcome of reconstruction (MSTS 66.6%, TESS 69%), with no signs of local recurrence and regression of pulmonary metastases at 18 months after the last administration of Denosumab.
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