Combined Proximal Radius Reconstruction Following Resection for Oncological Indication
Language Czech Country Czech Republic Media print
Document type Case Reports, English Abstract, Journal Article
PubMed
40145589
DOI
10.55095/achot2024/068
- Keywords
- Denosumab, biological reconstruction., giant cell tumor of the bone, proximal radius, wide resection,
- MeSH
- Denosumab therapeutic use MeSH
- Adult MeSH
- Fibula transplantation MeSH
- Bone Density Conservation Agents therapeutic use MeSH
- Humans MeSH
- Bone Neoplasms * surgery pathology drug therapy MeSH
- Lung Neoplasms * secondary drug therapy MeSH
- Giant Cell Tumor of Bone * surgery drug therapy secondary pathology MeSH
- Radius * surgery pathology diagnostic imaging MeSH
- Bone Transplantation methods MeSH
- Treatment Outcome MeSH
- Plastic Surgery Procedures * methods MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Case Reports MeSH
- Names of Substances
- Denosumab MeSH
- Bone Density Conservation Agents MeSH
Early surgical treatment of giant cell tumour of the bone has very good functional outcomes with a relatively low risk of local recurrence and metastatic spread.In case of a pathologic fracture, extraosseous extension, and tumor location in an anatomically difficult area, surgical treatment may represent a big challenge with an uncertain functional outcome.Our case report presents a 35-year-old patient with a delayed diagnosis of giant cell tumor of the proximal radius of the dominant limb, with pulmonary metastases. Following neoadjuvant Denosumab therapy, with a major treatment effect on both the primary tumor and pulmonary metastases, we performed a wide resection and combined biological reconstruction with fibular autograft, radial head endoprosthesis, and comprehensive elbow ligament reconstruction.At 24 months after surgery, the patient is self-sufficient, capable of more physically demanding work, with a satisfactory functional outcome of reconstruction (MSTS 66.6%, TESS 69%), with no signs of local recurrence and regression of pulmonary metastases at 18 months after the last administration of Denosumab.
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