The Epstein-Barr virus (EBV), a member of the human gamma-herpesviruses, is intricately linked to various human malignancies. Current treatment options for EBV infection involve the use of acyclovir and its derivatives, which exhibit limited efficacy and are associated with drug resistance issues. Therefore, there is a critical need for new medications with more effective therapeutic actions and less susceptibility to resistance. This review explores the therapeutic promise of flavones and flavonols, naturally occurring molecules, against EBV and its correlated cancers. It thoroughly delves into the molecular mechanisms underlying the therapeutic efficacy of these compounds and scrutinizes their complex interplay in EBV-linked processes and cancer transformation by targeting key genes and proteins pivotal to both the viral life cycle and tumor development. Additionally, the review covers current research, highlights key findings, and discusses promising avenues for future investigations in the pursuit of targeted therapies against EBV and its related tumors.

• Klíčová slova
• EBV life cycle, EBV-associated cancers, Epstein–Barr virus, anticancer effects, antiviral properties, flavones, flavonoids, flavonols, host–EBV interaction, viral and cellular genes, viral and cellular proteins,
• MeSH
• antivirové látky * farmakologie   terapeutické užití   chemie   MeSH
• flavonoly * farmakologie   terapeutické užití   chemie   MeSH
• flavony * farmakologie   terapeutické užití   chemie   MeSH
• infekce virem Epsteina-Barrové * farmakoterapie   komplikace   virologie   MeSH
• lidé MeSH
• nádory * farmakoterapie   virologie   MeSH
• protinádorové látky farmakologie   terapeutické užití   MeSH
• virus Epsteinův-Barrové * účinky léků   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• antivirové látky * MeSH
• flavonoly * MeSH
• flavony * MeSH
• protinádorové látky MeSH