N4-acetylcytidine (ac4C) is a post-transcriptional RNA modification that plays a crucial role in the epitranscriptome, influencing gene expression and cellular function. This modification occurs at the cytosine base, where an acetyl group is installed to the nitrogen at the 4th position (N4). This co-transcription modification affects RNA stability, RNA structure, and translation efficiency. Recent studies have uncovered a potential link between RNA modifications and DNA repair mechanisms, suggesting that ac4C-modified or methylated RNAs may interact with factors involved in DNA repair pathways; thus, influencing the cellular response to DNA damage. Dysregulation of modified RNAs, including ac4C RNA, has been implicated in cancer development, where aberrant levels of these RNAs may contribute to oncogenic transformation by altering genome stability and the expression of key genes regulating cell proliferation, cell cycle progression, and apoptosis. Understanding the dynamics of modified RNAs offers promising insights into the role of epitranscriptome in DNA repair processes and cancer treatment.

• Keywords
• DNA damage repair, N-acetylcytidine, NAT10, RNA modifications, epigenetics, epitranscriptomics,
• MeSH
• Cytidine * analogs & derivatives   metabolism   MeSH
• Epigenesis, Genetic * MeSH
• Humans MeSH
• Neoplasms * genetics   metabolism   MeSH
• DNA Repair * MeSH
• RNA Processing, Post-Transcriptional * MeSH
• Gene Expression Regulation, Neoplastic MeSH
• RNA * metabolism   genetics   MeSH
• Transcriptome * MeSH
• Animals MeSH
• Check Tag
• Humans MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Review MeSH
• Names of Substances
• Cytidine * MeSH
• N-acetylcytidine MeSH Browser
• RNA * MeSH