Chickens represent one of the most important sources of animal protein for the human population. However, chickens also represent one of the most important reservoirs of Salmonella for humans. Measures to decrease the Salmonella incidence in chickens are therefore continuously sought. In this study, we tested feed supplementation with a mixture of C1 to C12 monoacylglycerides. At 0.7 and 1.5 kg per ton of feed, such supplementation significantly decreased Salmonella counts in the caecum but not in the liver. The chickens were infected on day 4 and the protective effect in the caecum was recorded on day 22 and 23 of life. Supplementation also decreased the inflammatory response of chickens to Salmonella infection determined by avidin, SAA, ExFABP, MMP7, IL1β, IL4I and MRP126 gene expression but did not affect immunoglobulin expression in the caecum. C1 to C12 monoacylglycerides can be used as a feed supplement which, if continuously provided in feed, decrease Salmonella counts in chickens just prior slaughter.

• Keywords
• Caecum, Chicken, Monoacylglyceride, Salmonella,
• MeSH
• Cecum microbiology   MeSH
• Diet veterinary   MeSH
• Animal Feed analysis   MeSH
• Chickens * MeSH
• Monoglycerides * administration & dosage   metabolism   MeSH
• Random Allocation MeSH
• Poultry Diseases * immunology   microbiology   prevention & control   MeSH
• Disease Resistance * drug effects   MeSH
• Dietary Supplements analysis   MeSH
• Salmonella enteritidis * physiology   MeSH
• Salmonella Infections, Animal * immunology   microbiology   prevention & control   MeSH
• Dose-Response Relationship, Drug MeSH
• Animals MeSH
• Check Tag
• Male MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Monoglycerides * MeSH