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Author
Alb, Miriam 1 Antoine, Chloé 1 Azarias, Guillaume 1 Binder, Stefanie 1 Birkenbihl, Colin 1 Calzone, Laurence 1 Clavreul, Solène 1 Demlova, Regina 1 Fandrei, David 1 Ferle, Maximilian 1 Fischer, Luise 1 Franke, Stefan 1 Fricke, Stephan 1 Fröhlich, Holger 1 Gagelmann, Nico 1 Garderet, Laurent 1 Hudecek, Michael 1 Hydren, Jay R 1 Jamarik, Jakub 1 Knockaert, Manon 1
- Organization
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Workplace
Bonn Aachen International Center for IT Univ... 1 CREATIC Faculty of Medicine Masaryk Universi... 1 Cellular Therapy and Immunobiology Working P... 1 Center for Scalable Data Analytics and Artif... 1 Center for Translational Immunology and Depa... 1 Chronic Malignancy Working Party Multiple My... 1 Collaborate Project Management Munich Germany 1 Department of Hematology Hemostaseology and ... 1 Department of Hematology Oncology and Tumori... 1 Department of Internal Medicine 2 Chair of C... 1 Department of Stem Cell Transplantation Univ... 1 European Society for Blood and Marrow Transp... 1 F Hoffmann LaRoche AG Basel Switzerland 1 Fraunhofer Institute for Algorithms and Scie... 1 Fraunhofer Institute for Cell Therapy and Im... 1 Fraunhofer Institute for Cell Therapy and Im... 1 HealthTree Foundation Inc Lehi UT USA 1 Hematology and Cellular Therapy Department H... 1 INSERM U900 Paris France 1 Information Technology for Translational Med... 1
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Most cited article - PubMed ID 39627220
Impact of T cell characteristics on CAR-T cell therapy in hematological malignancies
PubMed
40750653
PubMed Central
PMC12316993
DOI
10.1038/s41746-025-01809-6
PII: 10.1038/s41746-025-01809-6
Knihovny.cz E-resources
In (immune)oncology, virtual twins (VTs) offer patient-individual decision support. Nevertheless, current VTs do not incorporate the unique properties of engineered adoptive cellular immunotherapies (eACIs). Here, we outline the minimal design specifications for VTs for engineered ACIs (eACI-VTs) to model the complex interplay between cell product and patient physiology. We motivate utilizing VTs in eACIs to provide decision support and reflect on how eACI-VTs can support the widespread use of eACIs.
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