The effects were ascertained of two partial inverse agonists at benzodiazepine receptors (beta-CCE and FG 7142) on the incidence of timid (defensive-escape), aggressive, sociable and locomotor activities in both timid and aggressive singly-housed male mice, treated with drugs in paired interactions with untreated non-aggressive males. FG 7142 (5 mg/kg) and beta-CCE (8 mg/kg) increased defenses and escapes without producing other behavioral changes in timid mice. FG 7142 (20 mg/kg) and beta-CCE (1-8 mg/kg) moderately increased defenses and alert postures in aggressive mice and this effect was associated with marked reduction of aggressive behavior. FG 7142 (20 and 80 mg/kg) also decreased walking across cage in aggressive mice. It is concluded that beta-CCE and FG 7142 produced behavioral changes which could be interpreted as "anxiogenic".

• MeSH
• agrese účinky léků   MeSH
• antagonisté receptorů GABA-A * MeSH
• interpersonální vztahy MeSH
• karboliny farmakologie   MeSH
• myši inbrední ICR MeSH
• myši MeSH
• pohybová aktivita účinky léků   MeSH
• úniková reakce účinky léků   MeSH
• úzkost chemicky indukované   MeSH
• zvířata MeSH
• Check Tag
• mužské pohlaví MeSH
• myši MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• antagonisté receptorů GABA-A * MeSH
• beta-carboline-3-carboxylic acid ethyl ester MeSH Prohlížeč
• FG 7142 MeSH Prohlížeč
• karboliny MeSH