β-glucans are cell wall constituents of bacteria, yeast, fungi, and plants. They are not expressed in mammalian cells, but they are recognized by mammalian cells as pathogen-associated molecular patterns by pattern recognition receptors and thus act as biological response modifiers. This review summarizes data on the hematopoiesis-stimulating effects of β-glucans, as well as on their ability to enhance bone marrow recovery after an injury. β-glucans have been shown to support murine hematopoiesis suppressed by ionizing radiation or cytotoxic anti-cancer therapy. They also enhance stem cell homing and engraftment. Basically, two forms of β-glucan preparations have been investigated, namely particulate and soluble ones. β-glucans are generally well tolerated, the particulate forms showing a higher incidence of undesirable side effects. Taken together, the hematopoiesis-stimulating properties of β-glucans predetermine these biological response modifiers to ever increasing use in human medicinal practice.

• MeSH
• anemie chemicky indukované   farmakoterapie   MeSH
• beta-glukany škodlivé účinky   farmakologie   terapeutické užití   MeSH
• hematinika škodlivé účinky   farmakologie   terapeutické užití   MeSH
• hematopoéza účinky léků   účinky záření   MeSH
• lékové formy MeSH
• lidé MeSH
• protinádorové látky škodlivé účinky   MeSH
• radioterapie škodlivé účinky   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH
• Názvy látek
• beta-glukany MeSH
• hematinika MeSH
• lékové formy MeSH
• protinádorové látky MeSH