2-Amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines bearing two equal or different achiral or chiral phosphonoalkoxy chains have been prepared either by aromatic nucleophilic substitution of 2-amino-4,6-dichloropyrimidine or by alkylation of 4,6-dihydroxy-2-(methylsulfanyl)pyrimidine with appropriate phosphonate-bearing building block. Alkylation of 4,6-dihydroxy-2-(methylsulfanyl)pyrimidine proved to be the method of choice for efficient preparation of variety of bisphosphonates. The enantiomeric purity of selected compounds was determined by capillary electrophoresis. Antiviral activity of bisphosphonates is discussed.

• MeSH
• Alkylation MeSH
• Antiviral Agents chemical synthesis   chemistry   pharmacology   MeSH
• Diphosphonates chemical synthesis   chemistry   pharmacology   MeSH
• Electrophoresis, Capillary MeSH
• HeLa Cells MeSH
• HL-60 Cells MeSH
• Humans MeSH
• Molecular Structure MeSH
• Mice MeSH
• Cell Line, Tumor MeSH
• Nucleosides chemistry   MeSH
• Cell Proliferation drug effects   MeSH
• Pyrimidines chemical synthesis   chemistry   pharmacology   MeSH
• Drug Screening Assays, Antitumor MeSH
• Stereoisomerism MeSH
• Structure-Activity Relationship MeSH
• Animals MeSH
• Check Tag
• Humans MeSH
• Mice MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Research Support, N.I.H., Extramural MeSH
• Names of Substances
• Antiviral Agents MeSH
• Diphosphonates MeSH
• Nucleosides MeSH
• Pyrimidines MeSH