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Glucan particles as suitable carriers for the natural anti-inflammatory compounds curcumin and diplacone - Evaluation in an ex vivo model
D. Rotrekl, B. Devriendt, E. Cox, L. Kavanová, M. Faldyna, P. Šalamúnová, Z. Baďo, V. Prokopec, F. Štěpánek, J. Hanuš, J. Hošek
Language English Country Netherlands
Document type Journal Article
Grant support
NV16-27522A
MZ0
CEP Register
- MeSH
- Anti-Inflammatory Agents chemistry pharmacology MeSH
- beta-Glucans chemistry isolation & purification pharmacology MeSH
- Flavanones chemistry pharmacology MeSH
- Immunologic Factors chemistry isolation & purification pharmacology MeSH
- Interleukin-1beta metabolism MeSH
- Cells, Cultured MeSH
- Curcumin chemistry pharmacology MeSH
- Leukocytes, Mononuclear drug effects immunology metabolism MeSH
- Neutrophils drug effects immunology metabolism MeSH
- Drug Carriers * MeSH
- Drug Compounding MeSH
- Respiratory Burst drug effects MeSH
- Solvents chemistry MeSH
- Saccharomyces cerevisiae chemistry MeSH
- Sus scrofa MeSH
- Tumor Necrosis Factor-alpha metabolism MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
Natural compounds offer a wide spectrum of potential active substances, but often they have a poor bioavailability. To increase the bioavailability and bioactivity of the natural anti-inflammatory molecules curcumin and diplacone, we used glucan particles (GPs), hollow shells from Saccharomyces cerevisiae composed mainly of β-1,3-d-glucan. Their indigestibility and relative stability in the gut combined with their immunomodulatory effects makes them promising carriers for such compounds. This study aimed to determine how curcumin and diplacone, either alone or incorporated in GPs, affect the immunomodulatory activity of the latter by assessing the respiratory burst response and the secretion of pro-inflammatory cytokines by primary porcine innate immune cells. Incorporating curcumin and diplacone into GPs by controlled evaporation of the organic solvent substantially reduced the respiratory burst response mediated by GPs. Incorporated curcumin in GPs also reduced GPs mediated secretion of IL-1β and TNF-α by innate immune cells. The obtained results indicate a potentially beneficial effect of the incorporation of curcumin or diplacone into GPs against inflammation.
Department of Analytical Chemistry University of Chemistry and Technology Prague Czech Republic
Department of Chemical Engineering University of Chemistry and Technology Prague Czech Republic
Department of Immunology Veterinary Research Institute Brno Czech Republic
References provided by Crossref.org
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