The first three children with Puumala virus nephropathy diagnosis in the Czech Republic are reported on. A boy and two girls were admitted with symptoms of interstitial nephritis. The medical history in all children revealed flu-like symptoms. All patients were mildly pyrexial and had elevated erythrocytes sedimentation rate, C-reactive protein and low hemoglobin levels. Serum creatinine levels were elevated and proteinuria exceeded 700 mg/L in all children. Tubular proteinuria, glycosuria, high urinary N-acetyl-beta-D-glucosaminidase levels and alpha-1-microglobulin levels confirmed the tubular lesion. Renal biopsies revealed a uniform pattern and showed non-purulent interstitial nephritis in all patients. Puumala virus antigen antibodies were detected in the plasma. All patients were treated with steroids and urine abnormalities and renal function returned to normal within 4 weeks. Hantavirus infection should be considered as one of possible causes of interstitial nephritis with decreased GFR in children even in areas with a low incidence of this infection.

• MeSH
• Diagnosis, Differential MeSH
• Child MeSH
• Hantavirus Infections diagnosis   epidemiology   MeSH
• Orthohantavirus * MeSH
• Hemorrhagic Fever with Renal Syndrome diagnosis   physiopathology   MeSH
• Humans MeSH
• Adolescent MeSH
• Disease Progression MeSH
• Puumala virus * MeSH
• Check Tag
• Child MeSH
• Humans MeSH
• Adolescent MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Case Reports MeSH

• MeSH
• Hantavirus Infections epidemiology   immunology   prevention & control   MeSH
• Orthohantavirus immunology   isolation & purification   MeSH
• Rodentia virology   MeSH
• Immunoglobulin G analysis   MeSH
• Immunoglobulin M analysis   MeSH
• Humans MeSH
• Antibodies, Viral blood   MeSH
• Seroepidemiologic Studies MeSH
• Animals MeSH
• Check Tag
• Humans MeSH
• Male MeSH
• Female MeSH
• Animals MeSH
• Publication type
• Letter MeSH
• Research Support, Non-U.S. Gov't MeSH
• Geographicals
• Czech Republic epidemiology   MeSH
• Names of Substances
• Immunoglobulin G MeSH
• Immunoglobulin M MeSH
• Antibodies, Viral MeSH