Gastrointestinal (GI) diseases are frequently diagnosed in rodents. Clinical signs are usually nonspecific and include anorexia, weight loss, chronic wasting, abdominal discomfort, gas accumulation in the intestine and stomach, and diarrhea. Malabsorption associated with GI dysfunction or gastroenteritis quickly leads to negative energy balance and metabolic acidosis. Therefore, all disorders of the GI tract should be treated as soon as possible. The article describes selected disorders of the GI tract in guinea pigs (Cavia porcellus), chinchillas (Chinchilla lanigera), degus (Octodon degus), and rats (Rattus norvegicus).

• Klíčová slova
• Chinchilla, Degu, Enteritis, Gastric dilatation and volvulus, Gastrointestinal disease, Guinea pig, Hamster, Rat,
• MeSH
• gastrointestinální nemoci * veterinární   diagnóza   terapie   MeSH
• hlodavci * MeSH
• krysa rodu Rattus MeSH
• morčata MeSH
• nemoci hlodavců * diagnóza   terapie   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• morčata MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

Adrenal gland disease has been described as a rare disease in pet rabbits and rodents. Hyperadrenocorticism with excessive secretion of corticosteroids is most commonly observed in guinea pigs and hamsters, with dermatologic signs similar to those seen in dogs. Diagnosis is based on clinical signs, diagnostic imaging such as abdominal ultrasound, and determination of the blood hormone concentrations. In guinea pigs, an adrenocorticotrophic hormone stimulation test with the measurement of salivary cortisol or corticosterone concentrations is recommended. The recommended treatment of adrenal disease in guinea pigs and hamsters is oral administration of trilostane or ketoconazole; surgical treatment is also possible.

• Klíčová slova
• Adrenal, Cushing, Guinea pig, Hamster, Hyperadrenocorticism, Hypertestosteronism, Rabbit, Trilostane,
• MeSH
• králíci MeSH
• křečci praví MeSH
• morčata MeSH
• nemoci hlodavců diagnóza   MeSH
• nemoci nadledvin * veterinární   diagnóza   terapie   MeSH
• zvířata MeSH
• Check Tag
• králíci MeSH
• křečci praví MeSH
• morčata MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH

BACKGROUND: There are currently few reports on the normal urinary protein-to-creatinine (UPC) ratio of guinea pigs, and there is little information on the effects of age and sex on this parameter. METHODS: Urinary protein and creatinine concentrations were measured in a total of 161 clinically healthy guinea pigs, and the UPC ratio was subsequently calculated. The effect of age and sex on these parameters was assessed using Mann-Whitney U tests. Using these data, UPC ratio reference ranges were established. RESULTS: Guinea pig pups younger than 6 months had a significantly higher UPC ratio than adult animals (median UPCs of 1.48 and 0.56, respectively). There was no effect of sex on this parameter. The reference range for the UPC ratio in adult guinea pigs was set at 0.12-2.21. For guinea pigs younger than 6 months, the reference range for the UPC ratio was set at 0.4-3.1. LIMITATIONS: This study was limited by the lack of blood analysis, which could reveal a subclinical health problem that could affect renal function and the extent of proteinuria. CONCLUSION: In guinea pigs, the UPC ratio is influenced by age but not by sex. Therefore, the reference range established for adult guinea pigs cannot be used for pups younger than 6 months.

• Publikační typ
• časopisecké články MeSH

Respiratory diseases (especially pneumonia) are very common disorders in pet rats. The suspected diagnosis is mostly based on the clinical signs, thoracic auscultation, and thoracic radiography. However, auscultation is insensitive in determining the severity of the disease, and radiographs are often unremarkable. Non-cardiac thoracic ultrasonography is increasingly used in veterinary medicine; however, it has not been described in detail in rats. Thoracic ultrasonic examination was conducted on 400 client-owned conscious pet rats. The rats were examined in the period from June 2023 to August 2023 in two veterinary clinics. Due to the small size of the animal, different anatomical considerations, and different evaluation protocols, as well as to meet the optimal outcome of detailed thoracic ultrasound, a standard methodological protocol was developed, and the name RATTUS (Rat Thoracic Ultrasound) was proposed. Typical signs of normal RATTUS were described (bat sign, lung sliding, A-lines, abdominal curtain sign, ski jump sign, lung pulse, seashore sign in M-mode, and bamboo sign). The new evaluation of lung inflation symmetry by substernal access was also described. The methodical approach presented and the normal findings description are proposed to be used for a standard/routine thoracic ultrasound examination in pet rats.

• Klíčová slova
• RATTUS, lung, pleura, rat, respiratory disease, thorax, ultrasonography,
• Publikační typ
• časopisecké články MeSH

OBJECTIVE: To report the prevalence and document the treatment and outcome of odontogenic abscesses and associated jaw osteomyelitis in pet rabbits. ANIMALS: 200 client-owned rabbits. METHODS: Pet rabbits surgically treated using extraoral teeth extraction with marsupialization for abscesses of dental origin and jaw osteomyelitis were included in the study (February 2018 to February 2023). A case must have had pre- and postoperative computed tomographic study and a follow-up period of at least 4 months. RESULTS: In total, 113 male and 87 female rabbits were treated surgically. The mean age at the time of the diagnosis at the authors' clinic was 3 years and 11 months. Male rabbits suffered from odontogenic abscesses significantly more often than females. The mean surgical time varied from 25 to 95 minutes, based on the severity of the pathology and location. The wound healed completely in an average of 39.7 days (range, 14 to 145 days; 95% CI, 36.9 to 42.5 days). Major complications detected in 18.5% (37/200) cases were associated with prolonged healing time mostly due to the formation of a bone sequestrum and gingival suture failure. The disease-free time following abscess resolution was on average 29 months (range, 4 to 60 months). The recurrence of the odontogenic infection was 8% (16/200 cases). CLINICAL RELEVANCE: The radical surgical technique with the extraction of all the infected teeth with the removal of all affected tissue and osteomyelitic bone and regular follow-up wound management is an effective method for the treatment of odontogenic abscesses with jaw osteomyelitis.

• Klíčová slova
• abscess, dentistry, extraction, osteomyelitis, rabbit,
• MeSH
• absces * chirurgie   veterinární   MeSH
• debridement veterinární   MeSH
• diagnostické zobrazování MeSH
• hojení ran MeSH
• králíci MeSH
• lidé MeSH
• osteomyelitida * chirurgie   veterinární   MeSH
• zvířata MeSH
• Check Tag
• králíci MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH

Meloxicam is a commonly used analgesic in rabbits. However, its possible impact on lymphocyte subpopulations remained unknown. The aim of the study was to investigate a possible effect of long-term administration of meloxicam on rabbit lymphocyte subpopulations. The study included 8 rabbits given meloxicam orally once daily (1 mg/kg BW) for 14 days and 8 rabbits as a control group. Peripheral blood samples were collected on day 0 (before the first dose of meloxicam), day 3, 7 and 14. Samples were evaluated with a haematology analyser and a flow cytometer. A significant decrease in T: B cell ratio was found in all samples taken during meloxicam administration compared to day 0, as well as in comparison with the control group (P < 0.01). A significant increase (P < 0.05) in proportion of CD5 +CD8 + lymphocytes occurred by day 3. Subsequently, although the values slightly decreased, they still remained elevated throughout all the experiment compared to the values from day 0 (P < 0.05). A slight decrease in T and B cell activation (CD5 +CD25 + and IgM+CD25 +) noticed by day 3, declined during the next days of administration and became more and more significant (finally, P = 0.0078). Since a high significant decrease (P < 0.01) in both T and B cell activation as well as a significant increase (P < 0.05) in CD5 +CD8 + T cells proportion were observed after meloxicam administration, a predicted effect of long-term administration of meloxicam on rabbit lymphocytes was confirmed.

• Klíčová slova
• CD25, CD8 T cells, Flow Cytometry, NSAIDs, T: B cell ratio,
• MeSH
• aktivace lymfocytů MeSH
• CD8-pozitivní T-lymfocyty * MeSH
• králíci MeSH
• meloxikam farmakologie   MeSH
• podskupiny lymfocytů * MeSH
• průtoková cytometrie veterinární   MeSH
• zvířata MeSH
• Check Tag
• králíci MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• meloxikam MeSH

The incidence of cardiac diseases in pet rabbits and rodents increased over the past decade as these species live longer and diagnostics methods are more precise to diagnose heart diseases even in small-sized animals. The article summarizes diagnostics of cardiac diseases in selected exotic companion mammals, particularly in rabbits, guinea pigs, chinchillas, and rats. The emphasis of the paper is given on clinical examination, thoracic radiography, electrocardiography, and echocardiography.

• Klíčová slova
• Cardiac disease, Chinchilla, Echocardiography, Electrocardiography, Guinea pig, Rabbit, Radiography, Rat,
• MeSH
• činčila MeSH
• hlodavci MeSH
• kardiologie * MeSH
• králíci MeSH
• krysa rodu Rattus MeSH
• morčata MeSH
• nemoci srdce * diagnóza   veterinární   MeSH
• savci MeSH
• zvířata MeSH
• Check Tag
• králíci MeSH
• krysa rodu Rattus MeSH
• morčata MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

Despite their high prevalence, the aetiopathogenesis of ovarian cysts in guinea pigs (Cavia porcellus) is unknown. We examined tissue samples of cystic ovaries from 20 guinea pigs by histopathology and immunohistochemistry for CD10 antigen, and determined the concentrations of Na+, K+, Cl-, oestradiol and progesterone in the cyst fluid. Cystic rete ovarii were found in all 20 guinea pigs but no follicular cysts. Concentrations of Na+ (142.2 ± 5.04 mmol/l), K+ (5.6 ± 0.76 mmol/l) and Cl- (116.1 ± 5.25 mmol/l) corresponded to extracellular, rather than intracellular, fluid indicating that rete ovarii cysts in guinea pigs are transudative in nature. A positive correlation was found between Na+ and Cl- concentrations (r = 0.7713, P <0.0001). The mean concentrations of oestradiol (61.9 ± 17.44 pg/ml) and progesterone (2.7 ± 5.42 ng/ml) in the cyst fluid were higher than expected because the rete epithelium is not known to have steroidogenic activity. A negative correlation was found between oestradiol and progesterone concentrations in cyst fluid (r = -0.4296, P = 0.0178). Possible pathogenetic mechanisms of cystic rete ovarii in guinea pigs are discussed.

• Klíčová slova
• CD10, cystic rete ovarii, immunohistochemistry, sex hormones,
• MeSH
• cystická tekutina MeSH
• elektrolyty MeSH
• estradiol MeSH
• morčata MeSH
• ovariální cysty * veterinární   MeSH
• progesteron * MeSH
• zvířata MeSH
• Check Tag
• morčata MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• elektrolyty MeSH
• estradiol MeSH
• progesteron * MeSH

Adverse effects of high dietary phosphorus on bone health have been observed in both animal and human studies. The aim of the investigation was to examine chronic effects of high phosphorus diet on the apical mandibular cortical thickness and volume in a hystricomorph rodent (Octodon degus) using microcomputed tomography. Male degus were randomly divided into two groups fed by different mineral contents from the age of 12 weeks till the age of 17 months. The micro-CT scanning and wall thickness analysis were applied on the region of the mandible exactly under the apices of the 4th premolar tooth, first molar tooth, and second molar tooth in two animals from each group. General overview and mapping of the ventral mandibular bone thickness revealed pronounced bony mandibular protrusions in all the animals fed a high-phosphorus diet with obvious bone thinning apically to the 4th premolar and first and second molar tooth apices. Mandibular bone volume and thickness located apically to the premolar and molars were statistically significantly smaller/thinner in the group fed by a high phosphorus diet. The thinnest bone measured 0.004 mm, where the mandibular 4th premolar tooth almost perforated the mandibular cortex. Similar studies of metabolic bone disease and its influence on alveolar bone were also published in rats and mice. The influence of different environmental, infectious, or metabolic factors on the growing tooth, alveolar bone formation, and bone pathologies must be done experimentally on growing animals. In contrast, degus have continuously growing dentition, and the effect of any of the above listed factors can be studied in this animal model at any age and for longer time periods.

• Klíčová slova
• cortical bone, degu (Octodon degus), dental disease, dentistry, micro-CT, rodent, volume thickness,
• Publikační typ
• časopisecké články MeSH

Although laboratory rabbits are commonly used as models of appendicitis in man, spontaneous appendicitis was only described ante-mortem in one pet rabbit with an acute abdomen. The aim of this article is to describe two spontaneous cases of appendicitis in pet rabbits, to describe therapeutic appendectomy, and to discuss the microbial flora of the inflamed appendix. A 5-month-old intact female and a 16-month-old, neutered male were presented to the veterinary clinic with restlessness, anorexia, and reduced faecal output. The main clinical findings were restlessness, severe discomfort on abdominal palpation, a mid-abdominal palpable tubulous mass and an elevated rectal temperature. Blood analyses showed lymphocytosis, monocytosis, and hyperglycaemia. Radiography was inconclusive. Abdominal ultrasound revealed a presence of a tubular structure with wall thicknesses of 4.2 and 3.7 mm in the two rabbits, respectively. The tubular structure had a rounded, closed end, and a multilayered wall, suggestive of appendicitis. Due to metabolic acidosis and poor prognosis, the first rabbit was euthanized. In the 16-month-old rabbit, appendectomy was performed. Recovery was uneventful, and 4 h after surgery, the rabbit started to become normally active. Postoperative care consisted of fluid therapy, multimodal analgesia, supportive care and prokinetics. Follow-up examinations at 10 days, 1 month, and at 11 months after the surgery did not show any abnormal clinical or laboratory findings. Histopathological examination of appendices from both rabbits showed gangrenous appendicitis. Aerobic cultivation showed the presence of pure culture of Klebsiella variicola sensitive to enrofloxacin, marbofloxacin, tetracycline, cefuroxime, trimethoprim sulphonamide, neomycin, and gentamicin. Restlessness associated with anorexia, abdominal pain, palpable abdominal mass, hyperglycaemia, lymphocytosis, and elevated rectal temperature may be indicative of inflammation within the gastrointestinal tract. Abdominal ultrasound is recommended in rabbits with showing these clinical signs because radiography can be inconclusive. Appendicitis is a life-threatening condition, which should be included into the list of differential diagnoses; for the rabbit, an acute abdomen and gastrointestinal stasis syndrome and must be treated immediately. K. variicola may be associated with appendicitis in rabbits as a causative agent or in association with appendix intraluminal dysmicrobia.

• Klíčová slova
• Klebsiella, acute abdomen, appendicitis, appendix, gastrointestinal stasis, rabbit,
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH