MYC is a target of the Wnt signalling pathway and governs numerous cellular and developmental programmes hijacked in cancers. The amplification of MYC is a frequently occurring genetic alteration in cancer genomes, and this transcription factor is implicated in metabolic reprogramming, cell death, and angiogenesis in cancers. In this review, we analyse MYC gene networks in solid cancers. We investigate the interaction of MYC with long non-coding RNAs (lncRNAs). Furthermore, we investigate the role of MYC regulatory networks in inducing changes to cellular processes, including autophagy and mitophagy. Finally, we review the interaction and mutual regulation between MYC and lncRNAs, and autophagic processes and analyse these networks as unexplored areas of targeting and manipulation for therapeutic gain in MYC-driven malignancies.
- Klíčová slova
- MYC, autophagy, gene regulatory networks (GRNs), lncRNAs,
- MeSH
- autofagie * MeSH
- genové regulační sítě * MeSH
- lidé MeSH
- protoonkogenní proteiny c-myc genetika metabolismus MeSH
- regulace genové exprese u nádorů * MeSH
- RNA dlouhá nekódující genetika metabolismus MeSH
- RNA nádorová genetika metabolismus MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- MYC protein, human MeSH Prohlížeč
- protoonkogenní proteiny c-myc MeSH
- RNA dlouhá nekódující MeSH
- RNA nádorová MeSH
