The notion that alternative peptide substrates can be processed and presented to the MHC class I pathway has opened for new aspects on how the immune system detects infected or damaged cells. Recent works show that antigenic peptides are derived from intron sequences in pre-mRNAs target for the nonsense-mediated degradation pathway. Introns are spliced out co-transcriptionally suggesting that such pioneer translation products (PTPs) are synthesized on the nascent RNAs in the nuclear compartment to ensure that the first peptides to emerge from an mRNA are destined for the class I pathway. This illustrates an independent translation event during mRNA maturation that give rise to specific peptide products with a specific function in the immune system. The characterization of the translation apparatus responsible for PTP synthesis will pave the way for understanding how PTP production is regulated in different tissues under different conditions and will help designing new vaccine strategies.
- Klíčová slova
- Alternative mRNA translation products, MHC class I antigen presentation,
- MeSH
- buněčné jádro genetika imunologie MeSH
- CD8-pozitivní T-lymfocyty cytologie imunologie MeSH
- cytosol imunologie metabolismus MeSH
- dendritické buňky cytologie imunologie metabolismus MeSH
- fagozomy genetika imunologie MeSH
- introny MeSH
- lidé MeSH
- MHC antigeny I. třídy genetika imunologie MeSH
- peptidy genetika imunologie MeSH
- prekurzory RNA genetika imunologie MeSH
- prezentace antigenu genetika MeSH
- proteasomový endopeptidasový komplex genetika imunologie MeSH
- proteosyntéza imunologie MeSH
- sestřih RNA imunologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- MHC antigeny I. třídy MeSH
- peptidy MeSH
- prekurzory RNA MeSH
- proteasomový endopeptidasový komplex MeSH
