The relationship between the skin microbiome and probiotics in the healing of burn injuries has garnered significant attention in recent years. Burn injuries disrupt the delicate balance of the skin microbiome, leading to complications in the healing process. Probiotic therapies have emerged as promising interventions to restore microbial balance, inhibit biofilm formation, and accelerate tissue repair. Probiotics may also mitigate the risk of antibiotic-resistant infections, which is a major concern in burn units. By enhancing immune responses and stimulating the production of antimicrobial peptides, probiotics can effectively combat bacterial colonization and prevent the emergence of drug-resistant strains. A combination of probiotics with other therapies, such as phages or nanoparticles, holds significant promise for enhancing burn healing. This approach can effectively treat burn wounds by promoting wound healing synergy, preventing infection, modulating the immune response, and disrupting biofilms. Overall, the relationship between the skin microbiome and probiotics in burn wound healing has substantial potential to advance the field of burn wound management.

• Klíčová slova
• Burns, Microbiome, Probiotics, Therapeutics, Wounds and injuries,
• MeSH
• biofilmy účinky léků   MeSH
• hojení ran * účinky léků   MeSH
• kožní mikrobiom MeSH
• kůže * mikrobiologie   MeSH
• lidé MeSH
• mikrobiota * MeSH
• popálení * mikrobiologie   terapie   MeSH
• probiotika * terapeutické užití   aplikace a dávkování   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

The rapid evolution and spread of multidrug resistance among bacterial pathogens has significantly outpaced the development of new antibiotics, underscoring the urgent need for alternative therapies. Antimicrobial photodynamic therapy and antimicrobial sonodynamic therapy have emerged as promising treatments. Antimicrobial photodynamic therapy relies on the interaction between light and a photosensitizer to produce reactive oxygen species, which are highly cytotoxic to microorganisms, leading to their destruction without fostering resistance. Antimicrobial sonodynamic therapy, a novel variation, substitutes ultrasound for light to activate the sonosensitizers, expanding the therapeutic reach. To increase the efficiency of antimicrobial photodynamic therapy and antimicrobial sonodynamic therapy, the combination of these two methods, known as antimicrobial photo-sonodynamic therapy, is currently being explored and considered a promising approach. Recent advances, particularly in the application of nanomaterials, have further enhanced the efficacy of these therapies. Nanosensitizers, due to their improved reactive oxygen species generation and targeted delivery, offer significant advantages in overcoming the limitations of conventional sensitizers. These breakthroughs provide new avenues for treating bacterial infections, especially multidrug-resistant strains and biofilm-associated infections. Continued research, including comprehensive clinical studies, is crucial to optimizing nanomaterial-based antimicrobial photo-sonodynamic therapy for clinical use, ensuring their effectiveness in real-world applications.

• Klíčová slova
• Antimicrobial photodynamic therapy, Antimicrobial sonodynamic therapy, Microbial infections, Nanosensitizers, Photosensitizers,
• MeSH
• antibakteriální látky * farmakologie   terapeutické užití   MeSH
• Bacteria účinky léků   účinky záření   MeSH
• bakteriální infekce * farmakoterapie   terapie   MeSH
• fotochemoterapie * metody   MeSH
• fotosenzibilizující látky * farmakologie   terapeutické užití   MeSH
• lidé MeSH
• nanostruktury chemie   MeSH
• reaktivní formy kyslíku metabolismus   MeSH
• ultrazvuková terapie * metody   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• antibakteriální látky * MeSH
• fotosenzibilizující látky * MeSH
• reaktivní formy kyslíku MeSH