This work focused on the effect of Maca on lipid, anti-oxidative, and glucose parameters in hereditary hypertriglyceridemic (HHTg) rat. Maca (1%) was administred to rats as a part of a high-sucrose diet (HSD) for 2 weeks. Rosiglitazone (0.02%) was used as a positive control. Maca significantly decreased the levels of VLDL (very low density lipoproteins), LDL (low density lipoproteins), and total cholesterol, and also the level of TAG (triacylglycerols) in the plasma, VLDL, and liver. Maca, as well as rosiglitazone, significantly improved glucose tolerance, as the decrease of AUC (area under the curve) of glucose showed, and lowered levels of glucose in blood. The activity of SOD (superoxide dismutase) in the liver, the GPX (glutathione peroxidase) in the blood, and the level of GSH (glutathione) in liver increased in all cases significantly. Results demonstrate that maca seems to be promising for a positive influence on chronic human diseases (characterized by atherogenous lipoprotein profile, aggravated antioxidative status, and impaired glucose tolerance), and their prevention.

• MeSH
• antioxidancia farmakologie   MeSH
• cholesterol krev   MeSH
• glukosa metabolismus   MeSH
• glutathion metabolismus   MeSH
• glutathionperoxidasa metabolismus   MeSH
• hyperlipoproteinemie typ IV farmakoterapie   metabolismus   MeSH
• játra enzymologie   metabolismus   MeSH
• krysa rodu Rattus MeSH
• látky reagující s kyselinou thiobarbiturovou analýza   MeSH
• LDL-cholesterol krev   MeSH
• Lepidium chemie   MeSH
• metabolismus lipidů účinky léků   MeSH
• metabolismus sacharidů účinky léků   MeSH
• plocha pod křivkou MeSH
• potkani Wistar MeSH
• rostlinné extrakty farmakologie   MeSH
• superoxiddismutasa metabolismus   MeSH
• triglyceridy krev   MeSH
• VLDL-cholesterol krev   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• antioxidancia MeSH
• cholesterol MeSH
• glukosa MeSH
• glutathion MeSH
• glutathionperoxidasa MeSH
• látky reagující s kyselinou thiobarbiturovou MeSH
• LDL-cholesterol MeSH
• rostlinné extrakty MeSH
• superoxiddismutasa MeSH
• triglyceridy MeSH
• VLDL-cholesterol MeSH