The influence of maca (Lepidium meyenii) on antioxidant status, lipid and glucose metabolism in rat
Jazyk angličtina Země Nizozemsko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- antioxidancia farmakologie MeSH
- cholesterol krev MeSH
- glukosa metabolismus MeSH
- glutathion metabolismus MeSH
- glutathionperoxidasa metabolismus MeSH
- hyperlipoproteinemie typ IV farmakoterapie metabolismus MeSH
- játra enzymologie metabolismus MeSH
- krysa rodu Rattus MeSH
- látky reagující s kyselinou thiobarbiturovou analýza MeSH
- LDL-cholesterol krev MeSH
- Lepidium chemie MeSH
- metabolismus lipidů účinky léků MeSH
- metabolismus sacharidů účinky léků MeSH
- plocha pod křivkou MeSH
- potkani Wistar MeSH
- rostlinné extrakty farmakologie MeSH
- superoxiddismutasa metabolismus MeSH
- triglyceridy krev MeSH
- VLDL-cholesterol krev MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antioxidancia MeSH
- cholesterol MeSH
- glukosa MeSH
- glutathion MeSH
- glutathionperoxidasa MeSH
- látky reagující s kyselinou thiobarbiturovou MeSH
- LDL-cholesterol MeSH
- rostlinné extrakty MeSH
- superoxiddismutasa MeSH
- triglyceridy MeSH
- VLDL-cholesterol MeSH
This work focused on the effect of Maca on lipid, anti-oxidative, and glucose parameters in hereditary hypertriglyceridemic (HHTg) rat. Maca (1%) was administred to rats as a part of a high-sucrose diet (HSD) for 2 weeks. Rosiglitazone (0.02%) was used as a positive control. Maca significantly decreased the levels of VLDL (very low density lipoproteins), LDL (low density lipoproteins), and total cholesterol, and also the level of TAG (triacylglycerols) in the plasma, VLDL, and liver. Maca, as well as rosiglitazone, significantly improved glucose tolerance, as the decrease of AUC (area under the curve) of glucose showed, and lowered levels of glucose in blood. The activity of SOD (superoxide dismutase) in the liver, the GPX (glutathione peroxidase) in the blood, and the level of GSH (glutathione) in liver increased in all cases significantly. Results demonstrate that maca seems to be promising for a positive influence on chronic human diseases (characterized by atherogenous lipoprotein profile, aggravated antioxidative status, and impaired glucose tolerance), and their prevention.
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J Clin Invest. 1985 Aug;76(2):517-27 PubMed
Atherosclerosis. 2000 Dec;153(2):263-72 PubMed
Curr Atheroscler Rep. 2000 Nov;2(6):503-7 PubMed
J Nat Prod. 2003 Aug;66(8):1101-3 PubMed
Andrologia. 2002 Dec;34(6):367-72 PubMed
Circulation. 2003 Dec 2;108(22):2805-11 PubMed
J Lab Clin Med. 1976 Jun;87(6):1057-64 PubMed
J Agric Food Chem. 2005 Feb 9;53(3):690-3 PubMed
Cell Biol Toxicol. 2006 Mar;22(2):91-9 PubMed
Methods Enzymol. 1984;105:121-6 PubMed
Ann N Y Acad Sci. 1993 Mar 15;676:27-45 PubMed
Ann N Y Acad Sci. 1993 Jun 14;683:57-68 PubMed
Phytother Res. 2004 Jun;18(6):471-4 PubMed
Urology. 2000 Apr;55(4):598-602 PubMed
Lab Delo. 1986;(12):724-7 PubMed
Ann Intern Med. 2001 Jan 2;134(1):61-71 PubMed
J Clin Invest. 1955 Sep;34(9):1345-53 PubMed
Am J Physiol Heart Circ Physiol. 2004 Feb;286(2):H742-8 PubMed
Phytochemistry. 2002 Jan;59(1):105-10 PubMed
Circulation. 2005 Feb 1;111(4):465-71 PubMed
Anal Biochem. 1968 Oct 24;25(1):192-205 PubMed
J Nutr. 1987 Jun;117(6):1011-7 PubMed
Pharmacol Res. 2004 Aug;50(2):123-30 PubMed
Arch Latinoam Nutr. 2000 Jun;50(2):126-33 PubMed
Diabetes. 2004 Aug;53(8):2169-76 PubMed
